BACKGROUND Hand, foot and mouth disease (HFMD), a virus-induced infectious disease that usually affects infants and children, has an increased incidence in China in recent years. This study attempted to investigate the role of the Notch signaling pathway in the pathogenesis of HFMD. METHODS Eighty-two children diagnosed with HFMD were enrolled into this study. The HFMD group was further divid...

Binding of programmed death-1 (PD-1) with its ligands (PD-L1/2) transmits a co-inhibitory signal in activated T-cells that promotes T-cell exhaustion, leading to tumor immune evasion. The efficacy of antibodies targeting PD-1 and PD-L1 has led to a paradigm shift in lung cancer treatment but the prognostic and predictive value of tumor PD-L1 expression remains controversial. Evaluating PD-1, PD...

The aim of this study was to characterize NK (CD56(+)CD3(-)) and NKT-like cell (CD56(+)CD3(+)) responses early after chikungunya infection. Expression profiling and functional analysis of T/NK/NKT-like cells were performed on samples from 56 acute and 31 convalescent chikungunya patients and 56 control individuals. The percentages of NK cells were high in both patient groups, whereas NKT-like c...

We have analyzed the transmembrane signaling operating in human cytolytic lymphocytes lacking surface expression of the CD3/TCR complex. Peripheral blood lymphocytes were fractionated into CD3+ and CD3- on the FACS and cloned under limiting conditions in the presence of PHA and IL-2. Approximately 90% CD3+ and 10% CD3- cells underwent clonal expansion. Clones obtained from the CD3- fraction bel...

Regulatory T cells (Treg) play some important roles in allergic rhinitis. The most specific marker for Treg is FOXP3, a recently identified transcription factor that is essential for Treg development. In order to clarify the levels of Treg in allergic nasal mucosa, we studied the relationship between FOXP3-expressing cells and Th1-Th2 balance in nasal mucosa by means of immunohistochemistry. Hu...

We examined 23 patients aged 40 to 65 years (mean age 54.526.72) with a diagnosis of acute coronary syndrome (ACS) at admission, who underwent emergency or delayed stenting day later. All had arterial hypertension as concomitant disease. Upon additional examination, blood troponin levels were determined, ECG was performed in the time dynamics. Acute myocardial infarction ST elevation diagnosed ...

هدف: این پژوهش با هدف آزمون مدل روابط بین سبک‌های مقابله و خودکارآمدی حرفه‌ای استرس ادراک شده ناشی از حرفه‌های سلامت در گروهی پرستاران انجام شد. روش: همبستگی، 151 نفر شاغل بخش‌های اونکولوژی دانشگاه علوم پزشکی تهران به پرسشنامه باورهای شغلی برای (پیسانتی، لامباردو، لوسیدی، لازاری برتینی، 2008)، نسخة کوتاه سیاهه موقعیت‌های استرس‌زا (کوهن، جانگ استین، 2006) (ولفگانگ، 1988) پاسخ دادند. مفروض روش آم...