Terahertz sources based on intracavity difference-frequency generation in mid-infrared quantum cascade lasers (THz DFG-QCLs) have recently emerged as the first monolithic electrically pumped semiconductor sources capable of operating at room temperature across the 1- to 6-THz range. Despite tremendous progress in power output, which now exceeds 1 mW in pulsed and 10 μW in continuous-wave regime...

Drug-resistance acquisition through kinase gate-keeper mutations is a major hurdle in the clinic. Here, we determined the first crystal structures of the human FGFR4 kinase domain (FGFR4K) alone and complexed with ponatinib, a promiscuous type-2 (DFG-out) kinase inhibitor, and an oncogenic FGFR4K harboring the V550L gate-keeper mutation bound to FIIN-2, a new type-1 irreversible inhibitor. Rema...

There is currently considerable interest in terahertz (THz) difference frequency generation (DFG) utilizing near-resonant intersubband nonlinearity in quantum cascade lasers and other quantum well heterostructures. Such devices were shown to operate at room temperature, but their power demonstrated so far has been rather low. In all previous works the intracavity configuration was studied, in w...

A tunable mid-infrared continuous-wave (cw) spectroscopic source in the 3.4-4.5 micrometers region is reported, based on difference frequency generation (DFG) in a quasi-phase-matched periodically poled RbTiOAsO4 (PPRTA) crystal. DFG power levels of 10 microW were generated at approximately 4 micrometers in a 20-mm long PPRTA crystal by mixing two cw single-frequency Ti:Al2O3 lasers operating n...

This paper concerns area-efficient automatic hardware architecture synthesis and its optimization from dataflow graph(DFG) specification for fast HW/SW cosynthesis. A node in a DFG represents a coarse grain computation block such as FIR and DCT and a port in a block may consume multiple data samples per invocation, which distinguishes our approach from conventional behavioral synthesis and comp...

We continue the research on termination detection for synchronous algorithms in P systems [1]. This paper is the first attempt to relate the classical definitions of process status and activation assumptions in the usual distributed computing framework to P systems. We validate our approach by modelling a well-known synchronous termination detection algorithm, the Dijkstra-Feijen-Van Gasteren (...

A photoswitchable DFG-out kinase inhibitor has been developed. The activity of the can efficiently be regulated by light in both enzymatic and living cell assays.

Portable terahertz (THz) frequency comb sources are highly desired for applications in rotational molecular spectroscopy and sensing. To date, direct THz quantum cascade laser (QCL) generation is not achievable at room temperature. However, based on intracavity difference (DFG) mid-infrared (mid-IR) QCLs a promising alternative. Here, we present numerical study of DFG-QCL formation mid-IR self-...