A second chromosome male-specific lethal gene, maleless (mle), in D. melanogaster is described. It kills males but not females in homozygous condition, regardless of whether female parents are heterozygous or homozygous for mle. Many, if not most, homozygous males survive up to the third instar larval stage, but cannot pupate and die eventually as larvae. No interactions with sex-transforming g...

This paper examines GMM and ML estimation of econometric models and the theory of Hausman tests with sampling weights. Weighted conditional GMM can be more e$cient than weighted conditional MLE, an ine$cient alternative to full information MLE under choice-based sampling, unless regressions have homoscedastic additive disturbances or sampling weights are independent of exogenous variables. GMM ...

BACKGROUND Acute lung injury (ALI) is characterized by alveolar damage, increased levels of pro-inflammatory cytokines and impaired alveolar fluid clearance. Recently, we showed that the deletion of Apoptosis signal-regulating kinase 1 (ASK1) protects against hyperoxia-induced acute lung injury (HALI) by suppressing IL-1β and TNF-α. Previously, our data revealed that the suppressor of cytokine ...

BACKGROUND Antibacterial, immunomodulatory and antioxidant properties of aerial parts of Barleria lupulina Lindl were investigated in the present communication. METHODS The antibacterial, antioxidant and immunomodulatory properties of B. lupulina (methanol soluble leaf and stem extracts) was analyzed by minimum inhibitory concentration, total phenolic contents, DPPH radical scavenging activit...

Multicollinearity negatively affects the efficiency of maximum likelihood estimator (MLE) in both linear and generalized models. The Kibria Lukman (KLE) was developed as an alternative to MLE handle multicollinearity for regression model. In this study, we proposed Logistic Kibria-Lukman (LKLE) logistic We theoretically established superiority condition new over MLE, ridge (LRE), Liu (LLE), Liu...

The existing methods for fitting mixture regression models assume a normal distribution for error and then estimate the regression parameters by the maximum likelihood estimate (MLE). In this article, we demonstrate that the MLE, like the least squares estimate, is sensitive to outliers and heavy-tailed error distributions. We propose a robust estimation procedure and an EM-type algorithm to es...

We formalize a new cryptographic primitive, Message-Locked Encryption (MLE), where the key under which encryption and decryption are performed is itself derived from the message. MLE provides a way to achieve secure deduplication (space-efficient secure outsourced storage), a goal currently targeted by numerous cloud-storage providers. We provide definitions both for privacy and for a form of i...

In this paper, we present a new maximum likelihood estimator (MLE) of carrier frequency offset for multicarrier signals in a frequency-selective Rayleigh fading channel. The proposed MLE is able to achieve wider estimation range of frequency offset with higher accuracy than previous blind approaches by exploiting the intrinsic structure of multicarrier signals. Simulations show that the estimat...

Determinantal point processes (DPPs) have wide-ranging applications in machine learning, where they are used to enforce the notion of diversity in subset selection problems. Many estimators have been proposed, but surprisingly the basic properties of the maximum likelihood estimator (MLE) have received little attention. In this paper, we study the local geometry of the expected log-likelihood f...