Capsids of polyomaviruses--small, nonenveloped DNA viruses--consist of the major structural protein VP1 and the minor structural proteins VP2 and VP3. The contributions of the individual capsid proteins to functions of the viral particle, such as DNA encapsidation, cell receptor attachment, entry, and uncoating, are still not clear. Here we show that viruslike particles assembled in nuclei of i...

Cold atmospheric plasmas (CAPs) are increasingly used for treatment of complex surfaces in biomedical and biomaterials processing applications. However, the multivariable, distributed-parameter, nonlinear nature CAP dynamics plasma–surface interactions, coupled with sensitivity to exogenous disturbances, make their safe, reproducible effective operation challenging. This paper adopts a data-dri...

A lymphotropic papovavirus (LPV) archetypal regulatory region was amplified from DNA from the blood of an immunocompromised rhesus monkey. We believe this is the first nonserological evidence of LPV infection in rhesus monkeys.

BACKGROUND The 2016 World Health Organization guidelines recommend all children <3 years start antiretroviral therapy (ART) on protease inhibitor-based regimens. But lopinavir/ritonavir (LPV/r) syrup has many challenges in low-income countries, including limited availability, requires refrigeration, interactions with anti-tuberculous drugs, twice-daily dosing, poor palatability in young childre...

A new method for the design of fixed-order dynamic output-feedback Linear Parameter Varying (LPV) controllers for discrete-time LPV systems with bounded scheduling parameter variations is presented. Sufficient conditions for stability and induced l2-norm performance of an LPV system are given through a set of Linear Matrix Inequalities (LMIs) and exploited for design. Controller parameters appe...

Though the benefits of lung protective ventilation (LPV) in acute lung injury/acute respiratory distress syndrome (ALI/ARDS) have been known for more than a decade, widespread clinical adoption has been slow. Han and colleagues demonstrate that women with ALI/ARDS are less likely than men to receive LPV, though this disparity resolves when the analysis is adjusted for patient height. This analy...

Purpose The FDA TLOVR algorithm has been commonly used to assess virologic response to antiretroviral (ARV) regimens. The FDA Snapshot algorithm has been proposed to replace the TLOVR algorithm, as it is simpler and is expected to yield similar results. Multiple studies determined that efficacy of LPV/r dosed once-daily (QD) + nucleoside reverse transcriptase inhibitors (NRTIs) was statisticall...

A method is presented for synthesizing output estimators and disturbance feedforward controllers for continuous-time, uncertain, gridded, linear parameter-varying (LPV) systems. Integral quadratic constraints (IQCs) are used to describe the uncertainty. Since gridded LPV systems do not have a valid frequencydomain interpretation, the time-domain, dissipation inequality approach is followed. The...

In this paper a new method for fixed-order output-feedback Linear Parameter Varying (LPV) controller design is presented. First, a set of stabilizing LPV controllers is given as an inner convex approximation of the non-convex set of all stabilizing LPV controllers with the same order. This characterization is based on the decoupling of the state and Lyapunov matrices appearing together in the d...

Ritonavir-boosted tipranavir (TPV/r) was evaluated as initial therapy in treatment-naïve HIV-1-infected patients because of its potency, unique resistance profile, and high genetic barrier. Trial 1182.33, an open-label, randomized trial, compared two TPV/r dose combinations versus ritonavir-boosted lopinavir (LPV/r). Eligible adults, who had no prior antiretroviral therapy were randomized to tw...