The purpose of this article is to provide a survey of the various stages in the development of response surface methodology (RSM). The coverage of these stages is organized in three parts that describe the evolution of RSM since its introduction in the early 1950s. Part I covers the period, 1951–1975, during which the so-called classical RSM was developed. This includes a review of basic experi...

Xanthomonas oryzae pv. oryzae, the causal agent of bacterial leaf blight in rice, contains a regulator that is encoded in the genome, designated OryR, which belongs to the N-acyl homoserine lactone (AHL)-dependent quorum-sensing LuxR subfamily of proteins. However, we previously reported that X. oryzae pv. oryzae does not make AHLs and does not possess a LuxI-family AHL synthase and that the Or...

Salvianolic acid A (Sal A), an important constituent of Radix Salviae Miltiorrhizae (RSM), is effective for the treatment of myocardial infarction (MI) and coronary heart disease due to its potential in the improvement of acute myocardial ischemia. However, its content is very low in RSM. So it is obvious to find a rich source of Sal A or to improve its content by conversion of other related co...

43 Preliminary proteomics studies (actual data is not given here) between tonic vs. phasic smooth 44 muscles identified three distinct protein spots identified to be those of SM22. The latter was 45 found to be distinctly down regulated in the internal anal sphincter (IAS) vs. rectal smooth 46 muscle (RSM) SMC. The major focus of the present studies was to examine the differential 47 molecular ...

Preliminary proteomics studies between tonic vs. phasic smooth muscles identified three distinct protein spots identified to be those of transgelin (SM22). The latter was found to be distinctly downregulated in the internal anal sphincter (IAS) vs. rectal smooth muscle (RSM) SMC. The major focus of the present studies was to examine the differential molecular control mechanisms by SM22 in the f...

This paper proposes Clock-RSM, a new state machine replication protocol that uses loosely synchronized physical clocks to totally order commands for geo-replicated services. Clock-RSM assumes realistic non-uniform latencies among replicas located at different data centers. It provides low-latency linearizable replication by overlapping 1) logging a command at a majority of replicas, 2) determin...

The resource space model (RSM) is a semantic data model based on orthogonal classification semantics for efficiently managing various resources in the future interconnection environment. This paper extends the RSM in theory by formalizing the resource space, investigating its characteristics from the perspective of set theory, defining the resource space schema and developing its normal forms. ...