OBJECTIVE To determine the clinical and laboratory parameters and the progression to insulin requirement in two groups of LADA patients separated according to GADA titers, and to evaluate the benefit of early insulinization in patients at high risk of premature beta-cell failure (high GADA titers). METHODS Among the diabetic adults seen at our service and screened for GADA at diagnosis, 54 we...

OBJECTIVE There is evidence that monocytes of patients with type 1 diabetes show proinflammatory activation and disturbed migration/adhesion, but the evidence is inconsistent. Our hypothesis is that monocytes are distinctly activated/disturbed in different subforms of autoimmune diabetes. RESEARCH DESIGN AND METHODS We studied patterns of inflammatory gene expression in monocytes of patients ...

Heterogeneity has been recently highlighted as a relevant characteristic of diabetes mellitus. The current classification of diabetes mellitus includes two main types of the disease, i.e. type 1 and type 2 diabetes. The latter is by far the most prevalent one. Nevertheless, there is a significant proportion of subjects with autoimmune diabetes mellitus that are classified as type 2 diabetic pat...

Aims: The objective of this study was to utilize C peptide levels to identify the patients suspected of having latent autoimmune diabetes in adults from clinically diagnosed type 2 diabetics. Methods:100 type 2 DM patients and 100 healthy controls were selected. All patients were assessed for fasting Cpeptide and insulin levels. Patients having C-peptide level<0.7 ng/ml were classified as suspe...

این پژوهش با الهام گرفتن از نتایج یک طرح مطالعاتی کاربردی، رویکرد سلسله­‌مراتبی جهت پیگیری فرایند توسعه تأمین‌کنندگان و حمایت تصمیمات موجود در هر مراحل آن ارائه‌ می‌کند. ابتدا، زمینه‌های تأمین نیازمند سپس واجد شرایط هریک زمینه‌ها به کمک تصمیم‌گیری چندشاخصه بهترین-بدترین مشخص می‌گردند. معیارهای شناسایی نیز مرور مطالعات پیشین بهره‌گیری نظرات خبرگان حوزه‌ی خرید استخراج‌شده‌اند. درنهایت، مدل ریاضی ...

P ositive islet cell–related autoantibody is thought to reflect the process of immune-mediated -cell damage symbolized by the insulitis, but there have been few reports on the pancreas histology of latent autoimmune diabetes in adults (LADA). We report a study of pancreas histology and a longitudinal insulin secretion in a LADA patient. A 50-year-old woman treated with sulfonylurea from the age...

Heterogeneity has been recently highlighted as a relevant characteristic of diabetes mellitus. The current classification of diabetes mellitus includes two main types of the disease, i.e. type 1 and type 2 diabetes. The latter is by far the most prevalent one. Nevertheless, there is a significant proportion of subjects with autoimmune diabetes mellitus that are classified as type 2 diabetic pat...

In 2012, cancer genomics saw the addition of a new phrase to its lexicon: kataegis, Greek for thunderstorm and an apt description for the discovery of localized regions of hypermutation that were revealed when numerous breast cancer genomes were sequenced in a landmark study in Cell. Michael Stratton from the Wellcome Trust Sanger Institute, UK, and fellow co-authors of the study speculated tha...

Star clusters are formed in molecular clouds which are believed to be the birth places of most stars. From recent observational data, Lada & Lada(2003) estimated that only 4 to 7% of the proto-clusters have survived. Many factors could cause this high infant mortality. Galactic tidal forces, close encounters with molecular clouds and shock heating are among the possible causes but they have a l...