Knitter, A. E., L. Panton, J. A. Rathmacher, A. Petersen, and R. Sharp. Effects of b-hydroxy-b-methylbutyrate on muscle damage after a prolonged run. J Appl Physiol 89: 1340–1344, 2000.—This study examined the effects of supplemental b-hydroxy-b-methylbutyrate (HMB) on muscle damage as a result of intense endurance exercise. Subjects (n 5 13) were paired according to their 2-mile run times and ...

OBJECTIVE To evaluate the role of immunohistochemical methods in the diagnosis of benign and malignant conjunctival melanocytic proliferations. DESIGN Retrospective immunohistopathologic study. METHODS Paraffin-embedded tissue sections from 20 conjunctival nevi and 15 invasive melanomas were immunoreacted with antibodies against cellular antigens S-100 protein, MART-1, HMB-45, CD-45, and Ki...

Hypersensitivity to mosquito bites (HMB) is a disorder characterized by a necrotic skin reaction and generalized symptoms subsequent to mosquito bites. It has been suggested that HMB is associated with chronic Epstein-Barr virus (EBV) infection and natural killer cell leukemia/lymphoma. We describe here a Korean child who had HMB associated with chronic EBV infection and natural killer cell lym...

In ovo feeding (IOF), injecting dietary components into the amnion about 1 d prior to internal pipping, may enhance growth by altering glycogen status. This hypothesis was evaluated with 5 IOF solutions containing protein, β-hydroxy-β-methylbutyrate (HMB), and carbohydrate. Four IOF treatments were arranged as a factorial of 2 levels of egg white protein (EWP; 0 and 18%) and 2 levels of HMB (0 ...

BACKGROUND β-hydroxy-β-methylbutyric acid (HMB) is an interesting supplement in sports. However, literature sources present a limited number of studies that verify the efficacy of HMB intake over a longer time period among endurance athletes. For this reason, the aim of this study was to assess the effect of HMB supplementation on physical capacity, body composition and levels of biochemical ma...

Intra-uterine growth restriction (IUGR) impairs postnatal growth and skeletal muscle development in neonatal infants. This study evaluated whether dietary β-hydroxy-β-methylbutyrate Ca (HMB-Ca) supplementation during the early postnatal period could improve muscle growth in IUGR neonates using piglets as a model. A total of twelve pairs of IUGR and normal-birth-weight (NBW) male piglets with av...

In the present study we have compared the effects of leucine supplementation and its metabolite β-hydroxy-β-methyl butyrate (HMB) on the ubiquitin-proteasome system and the PI3K/Akt pathway during two distinct atrophic conditions, hindlimb immobilization and dexamethasone treatment. Leucine supplementation was able to minimize the reduction in rat soleus mass driven by immobilization. On the ot...

The purpose of the present study was to determine the effects of short-term supplementation with the free acid form of b-hydroxyb-methylbutyrate (HMB-FA) on indices of muscle damage, protein breakdown, recovery and hormone status following a high-volume resistance training session in trained athletes. A total of twenty resistance-trained males were recruited to participate in a high-volume resi...

زمینه و هدف: کشتی ورزشی برخوردی با انقباض‌های برون‌گرای مکرر شدت بالاست. چنین فعالیت‌هایی که شدید انجام می‌گیرد، اختلالات مکانیکی متابولیکی همراه است. بالایی از فعالیت در به‌طور چشمگیری به تولید ناگهانی گونه‌های اکسیژن واکنش‌پذیر بنیان‌های آزاد حین رقابت بازیافت پس هر مسابقه منجر می‌شود، به‌طوری‌که حتی ممکن است طی این دسته فعالیت‌ها، ذخیرة ضداکسایشی به‌شدت کاسته تخلیه شود به‌دنبال ناکارامدی دست...