The promyelocytic leukemia (PML) protein forms nuclear bodies which are relocated to the cytoplasm by the RNA virus lymphocytic choriomeningitis virus (LCMV). The viral Z protein directly binds to PML and can relocate the nuclear bodies. Others have observed that LCMV virions may contain ribosomes; hence, we investigated the effects of infection on the distribution of ribosomal P proteins (P0, ...

The small-angle scattering (SAS) structure functions are analyzed for an idealized, random two-phase system: a stationary arrangement of hard puzzle particles, separated by a relatively thin interspace, which can be approximated by an interlayer. The detailed shape of the interlayer is defined by the shape of the particles themselves: The starting point for producing these initial particles is ...

It has recently become possible to screen thousands of markers to detect genetic causes of common diseases. Along with this potential comes analytical challenges, and it is important to develop new statistical tools to identify markers with causal effects and accurately estimate their effect sizes. Knowledge of the proportion of markers without true effects (p0) and the effect sizes of markers ...

CMSC828D notes (adapted from material written with Nail Gumerov). Work in progress 1 Acoustic Waves 1.1 Barotropic Fluids The usual assumptions for acoustic problems are that acoustic waves are perturbations of the medium (fluid) density ρ (r,t), pressure p (r,t), and mass velocity, v (r,t), where t is time. It is also assumed that the medium is inviscid, and that perturbations are small, so th...

BACKGROUND It has been proposed that the prion, the infectious agent of transmissible spongiform encephalopathies, is PrPSc, a post-translationally modified form of the normal host protein PrPC. We showed previously that mice devoid of PrPC (Prn-p0/0) are completely resistant to scrapie. We now report on the unexpected response of heterozygous (Prn-p0/+) mice to scrapie infection. MATERIALS A...

The Sugarcane yellow leaf virus (SCYLV) P0, a member of the highly heterologous proteins of poleroviruses, is a suppressor of posttranscriptional gene silencing (PTGS) and has additional activities not seen in other P0 proteins. The P0 protein in previously tested poleroviruses (Beet western yellows virus and Cucurbit aphid-borne yellows virus), suppresses local, but not systemic, PTGS induced ...

We carry out relativistic many-body calculations of the static and dynamic dipole polarizabilities of the ground 6s2 S0 and the first excited 6s6p P0 states of Yb. With these polarizabilities, we compute several properties of Yb relevant to optical lattice clocks operating on the 6s2 S0–6s6p P0 transition. We determine (i) the first four magic wavelengths of the laser field for which the freque...