Phospholemman (PLM, FXYD1) is a partner protein and regulator of the Na(+)-K(+)-ATPase (Na(+)-K(+) pump). We explored the impact of acute and short-term training exercise on PLM physiology in human skeletal muscle. A group of moderately trained males (n = 8) performed a 1-h acute bout of exercise by utilizing a one-legged cycling protocol. Muscle biopsies were taken from vastus lateralis at 0 a...

OBJECTIVE The aim of this study was to determine if the noninvasive or minimally invasive and nondestructive imaging techniques of quantitative T2-mapping or multiphoton microscopy (MPM) respectively, could detect differences in cartilage collagen orientation similar to polarized light microscopy (PLM). It was hypothesized that MRI, MPM, and PLM would all detect quantitative differences between...

OBJECTIVE To compare third-trimester size trajectory prediction errors (average transformed percent deviations) for three individualized fetal growth assessment methods. METHODS This study utilized longitudinal measurements of nine directly measured size parameters in 118 fetuses with normal neonatal growth outcomes. Expected value (EV) function coefficients and variance components were obtai...

Song, Jianliang, Xue-Qian Zhang, Lois L. Carl, Anwer Qureshi, Lawrence I. Rothblum, and Joseph Y. Cheung. Overexpression of phospholemman alters contractility and [Ca2 ]i transients in adult rat myocytes. Am J Physiol Heart Circ Physiol 283: H576–H583, 2002. First published May 2, 2002; 10.1152/ajpheart.00197.2002.—Previous studies showed increased phospholemman (PLM) mRNA after myocardial infa...

This publication discusses the evolution of CAD, CAM, and CAE tools through product data management systems into today’s product lifecycle management (PLM), followed by a review of the characteristics and benefits of PLM. Current practices and potential applications of PLM in aviation maintenance, repair and overhaul (MRO) are discussed through case studies, two of which were from the authors’ ...

The technique for efficiently managing management resources by ERP (Enterprise Resource Planning) and SCM (Supply-Chain Management) has been widely introduced in the manufacturing business before. Recently, PLM (Product Lifecycle Management) to which ERP and SCM is enhanced is spreading. PLM is paid to attention now by the technique for managing the product planning, the design, manufacturing, ...

Because phospholemman (PLM) regulates the Na(+)/K(+) pump (NKA) and is a major cardiac phosphorylation target for both protein kinase A (at Ser68) and protein kinase C (PKC) (at both Ser63 and Ser68), we evaluated whether PLM mediates the PKC-dependent regulation of NKA function and protein kinase A/PKC crosstalk in ventricular myocytes. PKC was activated by PDBu (300 nmol/L), and we measured N...

Secreted proteins of the Wnt family affect axon guidance, asymmetric cell division, and cell fate. We show here that C. elegans Wnts acting through Frizzled receptors can shape axon and dendrite trajectories by reversing the anterior-posterior polarity of neurons. In lin-44/Wnt and lin-17/Frizzled mutants, the polarity of the PLM mechanosensory neuron is reversed along the body axis: the long P...

Since 1958 pagano-Levin medium (PLM) has been used as an aid in the identification of Candida albicans. However, no statistical analysis of its effectiveness based on large number of random human specimens has been reported. The present study compared PLM (now called Candida test) with Sabouraud's plus antimicrobials and Littman's ox-gall agar without antimicrobials. Of 500 random vaginal sampl...