هدف: از چالش­های عمده بشریت افزایش افسردگی و اختلال عملکرد جنسی ناشی داروهای ضدافسردگی است. با توجه به نقش سلول­های سرتولی در اسپرماتوژنز، پژوهش حاضر، اثر داروی دولوکستین را بر زنده­مانی، آپوپتوزیس بیان ژن­های Bax و­ (Connexin 43) Cx43 بررسی کرده مواد روش‌‌ها: TM4 محیط DMEM/F12 حاوی %5/2 FBS، 5% سرم اسب %1 پنی سیلین-استرپتومایسین کشت شدند. دوزهای 30،60، 15، 5/7، 75/3 میکرو­گرم/ میلی­لیتر زمان­ه...

Introduction Candida palmioleophila is a rare human pathogenic fungus, which has been poorly characterized at the genome level. In this study, we reported first fatal case of C. infection in China and investigate microevolution host environment. Methods A series stains were collected from patient different time points for routine microbial drug sensitivity testing. The isolate 07202534 was iden...

Introduction: Greatly increased use of antifungal therapies has resulted in the development of multidrug resistant. The phenolic compound carvacrol have been reported to have anti-Candida activity. This work is an attempt to examine effect of carvacrol on ergosterol synthesis against multidrug resistant Candida albicans. Methods: This cross-sectional study has been conducted on 30 immune-compr...

Aim: The antimicrobial cetylpyridinium chloride (CPC) is used in the management of denture stomatitis-associated oral candidiasis as an alternative therapy well for hygiene. Cetylpyridinium survives cavity long periods at low doses, which fluctuates due to dynamics cavity. In this study, it was aimed evaluate impact different sub-therapeutic CPC concentrations (1/100, 1/200) time (0.,5., 2., 24...

Pharmacodynamics (PD) considers the relationship between drug exposure and effect. The two factors that have been used to distinguish the PD behaviors of antimicrobials are the impact of concentration on the extent of organism killing and the duration of persistent microbiologic suppression (postantibiotic effect). The goals of these studies were (i) to examine the relationship between antimicr...

A considerable number of fungal strains have developed resistant to various available antifungal agents due CPY, FKS and or ERG11 genes complicating coinfection cases SAR COV-2 virus. Therefore, this study sought isolate, identify azole polyene in pathogens isolated from confirmed SARS-CoV-2 individual Oyo State, Nigeria. Nasopharyngeal samples were collected symptomatic asymptomatic infected a...