OBJECTIVES To analyse the as yet unexplored genetic elements encoding erm(B)-mediated erythromycin resistance in tetracycline-susceptible pneumococci. METHODS Sixteen Streptococcus pneumoniae clinical isolates sharing erm(B)-mediated erythromycin resistance and susceptibility to tetracycline were used. Gene detection was performed by PCR using both established and specially designed primers. ...

This paper focuses on the product design process and the role played by environmental concerns during this critical stage. Specifically, we explore Environmentally Responsible Manufacturing (ERM) as perceived and acted on by two critical groups within this design process. The first consists of the champions and supporters of ERM. These are the people who either formally or informally act as adv...

The emergence of resistance to most antimicrobial agents in staphylococci indicates the need for new effective agents in the treatment of staphylococcal infections. Clindamycin is considered to be one safe, effective and less costly agent. We analysed 482 staphylococcal isolates. Detection of inducible clindamycin resistance was performed by the D-test, while the presence of methylases genes: e...

PIWI-interacting RNAs (piRNAs) are thought to silence transposon and gene expression during development. However, the roles of piRNAs in somatic tissues are largely unknown. Here we report the identification of 555 piRNAs in human lung bronchial epithelial (HBE) and non-small cell lung cancer (NSCLC) cell lines, including 295 that do not exist in databases termed as piRNA-like sncRNAs or piRNA-...

Previously we demonstrated that the sphingolipids ceramide and S1P (sphingosine 1-phosphate) regulate phosphorylation of the ERM (ezrin/radixin/moesin) family of cytoskeletal proteins [Canals, Jenkins, Roddy, Hernande-Corbacho, Obeid and Hannun (2010) J. Biol. Chem. 285, 32476-3285]. In the present article, we show that exogenously applied or endogenously generated S1P (in a sphingosine kinase-...

The symptoms of idiopathic epiretinal membranes (ERM) of the macula are blurred vision caused by the retinal dysfunction including photoreceptor dysfunction and metamorphopsia caused by retinal distortion. Surgical removal of ERM is reportedly associated with few complications, and surgical results are generally good [15]. Furthermore, we reported treating ERM and internal limiting membrane (IL...

In the previous class, we had described a universal learning algorithm, called ERM (Empirical Risk Minimization). Under the ERM principle, we want to learn a function f , and we are promised that this function belongs to the function class H. We are given a training set S, and the ERM algorithm returns a function h ∈ H that minimizes the error on the training sample. That is, h = argming∈H errS...

This paper responds to the lack of empirical evidence on how enterprise risk management (ERM) and financial performance small medium-sized enterprises (SMEs) are related. Structural equation modeling is used explore new mediators in relationship between ERM SME performance. The results show that organizational culture (mission dimension) strategic full positive These research highlight fact imp...

G protein-coupled receptor kinase 2 (GRK2) phosphorylates and desensitizes activated G protein-coupled receptors (GPCRs). Here, we identify ezrin as a novel non-GPCR substrate of GRK2. GRK2 phosphorylates glutathione S-transferase (GST)-ezrin, but not an ezrin fusion protein lacking threonine 567 (T567), in vitro. These results suggest that T567, the regulatory phosphorylation site responsible ...

Corynebacterium jeikeium is an opportunistic pathogen primarily of immunocompromised (neutropenic) patients. Broad-spectrum resistance to antimicrobial agents is a common feature of C. jeikeium clinical isolates. We studied the profiles of susceptibility of 20 clinical strains of C. jeikeium to a range of antimicrobial agents. The strains were separated into two groups depending on the suscepti...