نتایج جستجو برای: ژن tp53
تعداد نتایج: 23956 فیلتر نتایج به سال:
BACKGROUND Head and neck squamous cell carcinoma (HNSCC) is the sixth most common malignancy in the world in developed countries. Despite the intense research in the area of squamous cell carcinomas of head and neck (HNSCC), long-term survival rate has not changed significantly in this malignancy during recent decades. METHODS In this study, we focused on TP53 mutations in specific regions, i...
Individual mutations in the tumor suppressor TP53 alter p53 protein function. Some mutations create a non-functional protein, whereas others confer oncogenic activity, which we term 'oncomorphic'. Since mutations in TP53 occur in nearly all ovarian tumors, the objective of this study was to determine the relationship of oncomorphic TP53 mutations with patient outcomes in advanced serous ovarian...
Tp53, a stress response gene, is involved in diverse cell death pathways and its activation is implicated in the pathogenesis of Parkinson's disease. However, whether the neuronal Tp53 protein plays a direct role in regulating dopaminergic (DA) neuronal cell death or neuronal terminal damage in different neurotoxicant models is unknown. In our recent studies, in contrast to the global inhibitio...
The tumor suppressor gene TP53 is the most commonly mutated gene in human cancer. The reported prevalence of mutations in rhabdomyosarcoma (RMS) varies widely, with recent larger studies suggesting that TP53 mutations in pediatric RMS may be extremely rare. Overexpression of MDM2 also attenuates p53 function. We have performed TP53 mutation/MDM2 amplification analyses in the largest series anal...
TP53 and ataxia telangiectasia mutated (ATM) defects are associated with genomic instability, clonal evolution, and chemoresistance in chronic lymphocytic leukemia (CLL). Currently, therapies capable of providing durable remissions in relapsed/refractory TP53- or ATM-defective CLL are lacking. Ataxia telangiectasia and Rad3-related (ATR) mediates response to replication stress, the absence of w...
BACKGROUND The TP53 gene is one of the most frequently mutated genes amongst human malignancies, particularly TP53 codon 72 polymorphism. Furthermore, an association between the TP53 codon 72 variants and prostate cancer has been reported in several studies. Although some studies have indicated an association between the TP53 Arg/Arg variant and an increased risk for prostate cancer, other stud...
The genomic landscape of ALL is characterized by primary chromosomal abnormalities and a wide range of secondary deletions and mutations, which target key pathways implicated in leukemogenesis. There is a strong correlation between specific primary chromosomal abnormalities and the spectrum of cooperating mutations (see figure). Despite this extensive genetic heterogeneity, TP53 mutations have ...
ناباروری یک بیماری دستگاه تولید مثلی است که به صورت عدم موفقیت در باروری بعد از 12 ماه مقاربت جنسی منظم بدون جلوگیری تعریف می شود. از کل زوج ها، که به عنوان نابارور شناخته می شوند، حدود50-40% از علت های ناباروری مربوط به زنان، در 40-30% زوج های نابارور، علل ناباروری مربوط به مردان است، در حالیکه 30-10% از علل ناباروری هم مشترک بین زنان و مردان بوده ویا به صورت ناشناخته می باشد. لقاح مصنوعی از م...
زمینه و هدف : تنش های گوناگون نظیر پرتوهای یونیزان می توانند موجب افزایش آسیب های سلولی به خصوص در بخش هسته آن یعنی dna گردند. برای محافظت از این گونه آسیب ها، ژن های تنظیمی طبیعی مانند ژن سرکوب کننده تومور tp53 وارد عمل می گردند. دراین ارتباط، در بین شاغلین پرتوکاری که همواره با دوزهای پایینی از پرتوهای یونیزان سروکار دارند ،این ژن بررسی و میزان بروز آن با گروه کنترل مقایسه شد. روش کار: در ا...
TP53 has been implicated in regulation of the cell cycle, DNA repair, and apoptosis. We studied, in primary breast tumors through direct cDNA sequencing of exons 2-11, whether TP53 gene mutations can predict response in patients with advanced disease to either first-line tamoxifen therapy (202 patients, of whom 55% responded) or up-front (poly)chemotherapy (41 patients, of whom 46% responded). ...
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