BACKGROUND Treatment outcome after surgery alone is unsatisfactory in dogs with invasive malignant mammary gland tumors. HYPOTHESIS Adjuvant doxorubicin or docetaxel will improve the treatment outcome in dogs with high-risk malignant mammary gland tumors, and the use of docetaxel will be feasible in affected dogs. ANIMALS Thirty-one dogs with malignant mammary gland tumors of histologic sta...

0301-9322/$ see front matter 2014 Elsevier Ltd. All rights reserved. http://dx.doi.org/10.1016/j.ijmultiphaseflow.2013.12.007 ⇑ Corresponding author. Tel.: +1 515 294 1614; fax: +1 515 294 3262. E-mail addresses: [email protected] (J.D. Regele), jason.rabinovitch@caltech. edu (J. Rabinovitch), [email protected] (T. Colonius), [email protected] (G. Blanquart). J.D. Regele a,⇑, J. Rabi...

A Correction to this paper has been published: 10.1007/s12220-018-00104-z

A recent study by Dr. Maria Antonietta De Luca demonstrated intravenous (IV) self-administration responding (nose-poking) for the synthetic cannabinoid JWH-018 [1-pentyl-3-(1-naphthoyl)indole] (Figure 1) in an experimentally naïve, adult rat species [1]. This finding is unexpected since the phytocannabinoid (−)-trans-Δ9tetrahydrocannabinol (Δ9-THC, Figure 1), a primary psychoactive constituent ...

BACKGROUND Pycnocycla spinosa Decne. ex Boiss is an aromatic plant which showed relaxant effects on isolated ileum contractions and antidiarrheal activity. Thirty four components have been extracted from P. spinosa essential oil, of which several major constituents were found to show seasonal variation. OBJECTIVES The aim of this work is to evaluate the diurnal variation of its oil constituen...

On January 22nd 2009, the German Health Authorities prohibited several non-traditional cannabinoids, that proved to be the active components in popular "Bio-Designer-Drugs" like "Spice" and analogous products. The recent detection of CP 47,497-C8 in Europe and Japan documents that these products have already spread world wide. We synthesized several potentially interesting alkylaminoindoles (al...

Clostridium difficile is one of the main etiological agents causing antibiotic-associated diarrhea. This study investigated the genetic diversity of 70 toxigenic C. difficile isolates from two Korean hospitals by employing toxinotyping, ribotyping, multilocus sequence typing (MLST), and pulsed-field gel electrophoresis (PFGE). Toxin gene amplification resulted in 68 A⁺B⁺ and two A-B+ isolates. ...

(4) Pigmentation of Polymita picta (5) Pigmentation of Cepaea nemoralis (6) Conclusion . . . . . . . . (2) General characters of helicid pigmentation . . (3) Colour associations and interchangeability of pigments . . . . . . . . V. Summary . . . . . . . . . VI. References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . PAGE 285 286 288 288 289 289 292 2...

The miR-294 and miR-302 microRNAs promote the abbreviated G1 phase of the embryonic stem cell (ESC) cell cycle and suppress differentiation induced by let-7. Here, we evaluated the role of the retinoblastoma (Rb) family proteins in these settings. Under normal growth conditions, miR-294 promoted the rapid G1-S transition independent of the Rb family. In contrast, miR-294 suppressed the further ...

Mouse Embryonic Stem (ES) cells express a unique set of microRNAs (miRNAs), the miR-290-295 cluster. To elucidate the role of these miRNAs and how they integrate into the ES cell regulatory network requires identification of their direct regulatory targets. The difficulty, however, arises from the limited complementarity of metazoan miRNAs to their targets, with the interaction requiring as few...