Mycophenolic acid (MPA) is prescribed to prevent allograft rejection in organ transplanted patients. However, its use is sporadically linked to leak flux diarrhea and other gastrointestinal (GI) disturbances in around 75% of patients through yet unknown mechanisms. Recently, we identified Midkine as a modulator of tight junctions (TJs) permeability in MPA treated Caco-2 monolayer. In the presen...

OBJECTIVE To evaluate the microshear bond strength (μSBS) of self-adhesive resin (SA) cement on leucite-reinforced glass-ceramic using silane or universal adhesive. MATERIALS AND METHODS Ceramic blocks were etched with 9.5% hydrofluoric acid and divided into three groups (n = 16): (1) negative control (NC) without treatment; (2) Single Bond Universal (SBU); (3) RelyX Ceramic Primer as positiv...

In the present study, the authors investigated chromosomal fragility in patients with schizophrenia, and compared the patients, who were positive for minor physical anomalies (MPAs) with those who were negative for MPAs in respect to chromosome fragility. 44 patients with schizophrenia were examined and compared to 23 matched healthy controls. A modified Waldrop-scale was used for evaluation of...

The durability of resin-dentin bonds is a growing concern in the placement of composite restorations. Most reported evaluations concerning the mechanical behavior of the bonded interface are conducted using static loading to failure only. They also do not account for the acid production of biofilms, which is one of the most common contributors to interfacial failures in vivo. In this investigat...

During in vitro decidualization of human endometrial stromal cells (HESCs), medroxyprogesterone acetate (MPA) inhibits expression of the potent extracellular matrix (ECM)-degrading protease stromelysin-1 (MMP-3), but enhances PRL expression. Consistent with its priming role in vivo, estradiol (E2) augments these effects. In the current study, immunoblot analysis revealed that coincubation with ...