Bullous pemphigoid (BP) is a subcutaneous blistering skin disease in which IgG autoantibodies are formed against the hemidesmosomal protein BP180. Epidemiological studies have revealed strong association between an increased risk of BP and use dipeptidyl peptidase 4 inhibitors (DPP4i/gliptins), especially vildagliptin. We performed proteomic study on vildagliptin-exposed mice to reveal factors ...

Mailing address: Pedro José Negreiros de Andrade • Francisco Holanda, 992/1101 Dionisio Torres 60130-040 Fortaleza, CE Brazil E-mail: [email protected], [email protected] Manuscript received May 01, 2010; revised manuscript received July 14, 2010; accepted August 13, 2010.

1Department of Biochemistry, King George’s Medical University, Lucknow-226 003, India 2Department of Pediatric Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi221005, India 3Department of Orthopedic Surgery, King George’s Medical University, Lucknow-226 003, India 4Department of Transfusion Medicine, King George’s Medical University, Lucknow-226 003, India 5Department ...

we excluded the 2 patients with previously documented resistance from the analysis, we found that the trend for increasing ivermectin survival time remained significant (P=.006) (Table). Results from a single patient with recurrent CS and previously documented ivermectin resistance are of note (Figure). When this patient was treated again in 2006 with 3 doses of ivermectin (200 μg/ kg), no noti...

A potentially clinically important interaction has been described between clofibrate and ibuprofen in vitro. To determine whether this in vitro interaction is paralleled by a change in pharmacokinetics of ibuprofen in vivo two groups of rats were treated orally with clofibrate (n = 8, 280 mg/kg/day) or vehicle (n = 7) for 3 days. On day 3, 2 hr after the last dose of clofibrate, the rats were g...

The aim of this study was to examine the hormonal and strength responses to different periodization models of resistance training in male athletes. Eighteen experienced resistance trained males were randomly assigned to either a block (BP; n=10; age: 23.7±2.9 yr; body mass: 78.5±11.3 kg; height: 1.77±0.05 m) or weekly undulating (WUP; n=8; age: 26.0±5.7 y; body mass: 78.9±12.4 kg; height: 1.79±...

esults: Interrupted aortic arch was type A in 17 patients and type B in 3 patients. ortopulmonary window morphology was type I (n 10), type II (n 5), and type II (n 5). Associated cardiovascular anomalies were common, including atrial eptal defect (n 13) and systemic venous anomalies (n 3). Overall survival after nitial admission was 91%, 86%, and 84% at 1, 5, and 10 years, respectively. Fiftee...