In vitro, both carbohydrate sugars and artificial sweeteners (AS) stimulate the secretion of glucagon-like peptide-1 (GLP-1). It has been suggested that the gut tastes sugars and AS through the same mechanisms as the tongue, with potential effects on gut hormone release. We investigated whether the human gut responds in the same way to AS and carbohydrate sugars, which are perceived by lingual ...

The roles of PGI2 and TXA2 in recurring reduction of carotid artery and cerebral blood flow induced by partial constriction of the common carotid artery and cerebral blood flow induced by partial constriction of the common carotid artery were examined in anesthetized dogs. The recurring reduction was eliminated by OKY 046 and 1580 which inhibit TX synthetase, acetylsalicylic acid which inhibits...

The fundamental problems related to uncertainty in quantitative risk analyses, used in decision making in safety-related issues (for instance, in land use planning and licensing procedures for hazardous establishments and activities) are presented and discussed, together with the different types of uncertainty that are introduced in the various stages of an analysis. A survey of methods for the...

There is evidence that tumors may stimulate platelet aggregation, causing release of thromboxane A2. Thromboxane A2 may potentiate tumor metastasis by stimulating tumor cell growth and proliferation and by enhancing platelet-tumor cell aggregate formation. Despite potential significance of thromboxane A2 in tumor metastasis, agents which inhibit thromboxane A2 synthesis have not been uniformly ...

Various normative decision theories are discussed in the context of fire risk management. A method suitable for practical decision making in respect to fire safety investments is presented and exemplified. The method involves the use of second-order probabilities to represent uncertainty regarding probability values. A discussion on the use of Bayes theorem in combination with decision analysis...

AccuRhythm AI is a suite of cloud-based algorithms that filter and suppress false arrhythmia detections from insertable cardiac monitors (ICMs). Its initial release represented large reduction to remote monitoring burden, suppressing 74.1% AF alerts. Deploying performance updates easy with AI, but the adjudication effort train test becomes increasingly burdensome as improves. Ever larger datase...