Following the success of single agent CTLA-4 and PD-1 inhibition, focus has shifted to the study of novel combinations of immune therapeutics with the goal of improving efficacy. A major breakthrough was seen in CheckMate 067 as dual PD1/CTLA4 blockade demonstrated robust and often durable responses. However, this efficacy came at the cost of considerable toxicity, as ≥ 50% of patients on combi...

Homolateral Extremity Synkinesia after the Stroke Huseyin Buyukgol1*, Muzaffer Gunes2 and Fatma Aysen Eren2 1KTO Karatay University, Medicana Faculty of Medicine, Department of Neurology. Konya/Turkey 2Aksaray Training and Research Hospital. Department of Neurology. Aksaray/Turkey *Address for Correspondence: Huseyin Buyukgol, KTO Karatay University, Medicana Faculty of Medicine, Department of ...

This work presents a new access method (LES-tree) for spatio-temporal databases that handles discrete change events over objects’ spatial attributes. The main characteristic of this structure is that, in addition to the traditional database snapshots, LEStree explicitly stores the events in log structures associated with space partitions. The definition of this new access method aims to extend ...

Rice is an important crop throughout the world and is the staple food for about half the world's population. For better breeding and improved production, we need to know the function of rice molecules which facilitate their function through interactions with each other. The database of interacting proteins in Oryza sativa (DIPOS) provides comprehensive information of interacting proteins in ric...

We report the characterization of 6 Leishmania tropica isolates from 2 patients with visceral leishmaniasis who were unresponsive to treatment with sodium stibogluconate. The Leishmania isolates, MHOM/KE/81/NLB-029A, -029XIB, and -029XIC and MHOM/KE/81/NLB-030I, -030B, and -030XXA, all from splenic aspirates, were characterized by cellulose acetate electrophoresis using 11 enzymes: malate dehyd...

We have analysed the recent results from the observation of charged current νed → e pp events from solar neutrinos by the Sudbury Neutrino Observatory SNO assuming neutrino oscillations with three active flavours. The data seem to prefer a low mass-squared difference and large mixing angle solution (the so-called LOW solution) in (12) parameter space. However, when combined with the Gallium cha...

In Theory IIb we characterize with a mix of theory and experiments the optimization of deep convolutional networks by Stochastic Gradient Descent. The main new result in this paper is theoretical and experimental evidence for the following conjecture about SGD: SGD concentrates in probability like the classical Langevin equation – on large volume, “flat” minima, selecting flat minimizers which ...

This study examined the effect of weather and seasonality on hipfracture incidence in older adults residing in New York City. A total off 66,346 patients aged > or = 65 years who sustained a fracture of the femoralneck or intertrochanteric region from 1985 to 1996 comprised the study population. Hip fractures were more likely to occur in the winter than in any of the other seasons (P<.001). Fac...