In the title E isomer of the racemic compound, C37H32F2N2O2, the pyridinone ring adopts a twisted half-chair conformation with the N atom deviating by -0.355 (3) Å and with the methyl-ene C atom next to octa-hydro-indolizine moiety deviating by 0.415 (3) Å from the mean plane defined by other four atoms. In the octa-hydro-indolizine system, the pyrrolidine ring exhibits an envelope conformation...

In the title compound, C37H32Cl2N2O2, the pyridinone ring adopts a twisted half-chair conformation. The fused pyrrolidine and piperidine rings of the octa-hydro-indolizine unit exhibit envelope (with the C atom bound to the C atom bearing the chloro-benzene ring being the flap atom) and chair conformations, respectively. The dihedral angle between the chloro-benzene rings is 84.03 (1)°. In the ...

In the title compound, C(39)H(38)N(2)O(4), the pyridinone ring adopts a twisted half-chair conformation with the N atom deviating by 0.3304 (1) and with the methyl-ene C atom adjacent to the octa-hydro-indolizine unit deviating by 0.444 (3) Å from the mean plane defined by the other four atoms. In the octa-hydro-indolizine system, the pyrrolidine ring exhibits an envelope conformation, with the...

BackgroundOvarian reserve and normal oocyte ploidy are inversely correlated to maternal age. However, the effects of ovarian aging on blastocyst conversion rates is not clearly described in literature. Age-specific data this topic would be useful when counseling patients after an embryo cryopreservation cycle.ObjectiveTo determine blastulation cycles which yield at least one cryopreserved usabl...

Five new spiro[indoline-3,3′-indolizine]s have been synthesized with high regio- and stereospecificity in one-pot three-component reactions between a substituted indole-2,3-dione, ( S )-pipecolic acid trans -3-benzoylacrylic acid, subsequently characterized using combination of elemental analysis, IR 1 H 13 C NMR spectroscopy, mass spectrometry crystal structure analysis. (1′ SR ,2′ ,3 RS ,8a′ ...

1 0-6 (0.2) 3-4 (3-2) 5-2 (1.6) 1-2 (1-0) 2 0-6 (0) 1-5 (0) 1.5 (0) 2-8 (1-6) 3 0-5 (0.5) 0 1 (0) 0-9 (0-7) 3-8 (3 8) 4 8-1 (7-3) 43 (2.5) 6-9 (3-3) 17-0 (17-0) 5 52 (1-6) 46 (1)0) 0-8 (0-8) 43 (3.5) 6 0-2 (0-2) 0-2 (0-2) 0 1 (0( 1) 0 4 (0 3) 7 1-5 (1-5) 1 1 (1 0) 1-0 (0.6) 2-2 (2 2) 8 0-7 (0-6) 2-0 (2.0) 2-9 (2 9) 1 8 (()) 9 2-8 (0 8) 1-5 (0-4) 1-9 (0.6) 1 2 ((1.4) 10 5-5 (5.5) 27 (2.2) 1-2 ((...