BACKGROUND The beneficial effects of testosterone treatment (TT) are debated. METHODS Double-blinded, placebo-controlled study of six months TT (gel) in 54 men aged 60-78 with bioavailable testosterone (BioT) <7.3 nmol/L and waist >94 cm randomized to TT (50-100 mg/day, n = 20), placebo (n = 18), or strength training (ST) (n = 16) for 24 weeks. Moreover, the ST group was randomized to TT (n =...

Introduction Up to 80% of children with Juvenile Systemic Lupus Erythematosus (JSLE) develop lupus nephritis (LN) (1), with the 5-year renal survival rate varying between 44-94% (2-4). Conventional markers of JSLE disease activity fail to adequately predict impending LN flares (5), with significant renal involvement (class III, IV or V LN) known to occur with low level proteinuria (6). Cross-se...

We study the polynomial-time autoreducibility of NP-complete sets and obtain separations under strong hypotheses for NP. Assuming there is a p-generic set in NP, we show the following: • For every k ≥ 2, there is a k-T-complete set for NP that is k-T autoreducible, but is not k-tt autoreducible or (k − 1)-T autoreducible. • For every k ≥ 3, there is a k-tt-complete set for NP that is k-tt autor...

In this paper we conjecture that the piecewise linear map f(x) = px1I[0,1/p)(x)+ (sx − s/p)1I[1/p,1](x), p > 1, 0 < s < 1 which has an expanding, onto branch and a contracting branch is eventually piecewise expanding. We give a partial proof of the conjecture, in particular for values of p and s such that d− ln(p(1−s)+s) ln s e 6 = d− ln p ln s e.

Objective(s): lupus nephritis (LN) is a severe form of systemic lupus erythematosus (SLE) with renal complications. Current diagnosis is based on invasive renal biopsy and serum antibodies and complement levels that are not specific enough. The current study aims to identify new biomarker candidates for non-invasive diagnosis of LN and explore the pathogenic mechanisms...

The coordination ability of the pyridine derivative cyclic triimidazole, namely 3-(pyridin-2-yl)triimidazotriazine (TT-Py) towards Cu(I) was explored. TT-Py is an appealing nitrogen-rich ligand characterized by presence three imidazole nitrogen atoms with trigonal symmetry and a moiety, available for to metal ions. multidentate nature allows isolate, reaction CuI at room temperature, one-dimens...

Trinuclear rare-earth metal methylidene complexes with a Ln3(μ3-CH2)(μ3-Me)(μ2-Me)3 structural motif were synthesized by applying three protocols. Polymeric [LuMe3]n (1-Lu) reacts with the sterically demanding amine H[NSiMe3(Ar)] (Ar = C6H3iPr2-2,6) in tetrahydrofuran via methane elimination to afford isolable monomeric [NSiMe3(Ar)]LuMe2(thf)2 (4-Lu). The formation of trinuclear rare-earth meta...

Define the Linus sequence Ln for n ≥ 1 as a 0-1 sequence with L1 = 0, and Ln chosen so as to minimize the length of the longest repeated block Ln−2r+1 . . . Ln−r = Ln−r+1 . . . Ln. Define the Sally sequence Sn as the length r of the longest repeated block that was avoided by the choice of Ln. We prove several results about these sequences, such as exponential decay of the frequency of highly pe...

Abstract Background Bowel urgency, the sudden and immediate need to have a bowel movement, is common symptom in ulcerative colitis (UC) associated with higher disease activity, decreased work productivity markedly reduced quality of life1. This study explored differences burden among UC patients urgency based on their treatment pathway. Methods Data were extracted from Adelphi Disease Specific ...

Sequences (Ln | n > k), called streams, of regular languages Ln are considered, where k is some small positive integer, n is the state complexity of Ln, and the languages in a stream differ only in the parameter n, but otherwise, have the same properties. The following measures of complexity are proposed for any stream: (1) the state complexity n of Ln, that is, the number of left quotients of ...