نتایج جستجو برای: 1 mcp

تعداد نتایج: 2754053  

Journal: :Journal of immunology 2008
Shiva Shahrara Amanda E I Proudfoot Christy C Park Michael V Volin G Kenneth Haines James M Woods Christopher H Aikens Tracy M Handel Richard M Pope

Chemokines, including RANTES/CCL5 and MCP-1/CCL2, are highly expressed in the joints of patients with rheumatoid arthritis, and they promote leukocyte migration into the synovial tissue. This study was conducted to determine whether the inhibition of RANTES and MCP-1 therapeutically was capable of ameliorating rat of adjuvant-induced arthritis (AIA). Postonset treatment of AIA using a novel inh...

Journal: :Molecular pharmacology 2001
Y L Chang J J Shen B S Wung J J Cheng D L Wang

Wogonin (Wog), an active component of Scutellaria baicalensis, has antioxidant and anti-inflammatory properties. Monocyte chemotactic protein-1 (MCP-1), a potent chemoattractant for monocytes, plays a crucial role in case of early inflammatory responses, including atherosclerosis. In this study, we investigated the effect of Wog on phorbol ester (PMA)-induced MCP-1 expression in human umbilical...

Journal: :American journal of physiology. Regulatory, integrative and comparative physiology 2010
Carlo O Martinez Matthew J McHale Jason T Wells Oscar Ochoa Joel E Michalek Linda M McManus Paula K Shireman

Muscle regeneration requires CC chemokine receptor 2 (CCR2) expression on bone marrow-derived cells; macrophages are a prominent CCR2-expressing cell in this process. CCR2-/- mice have severe impairments in angiogenesis, macrophage recruitment, and skeletal muscle regeneration following cardiotoxin (CTX)-induced injury. However, multiple chemokines activate CCR2, including monocyte chemotactic ...

2013
Teizo Yoshimura Carole Galligan Munehisa Takahashi Keqiang Chen Mingyong Liu Lino Tessarollo Ji Ming Wang

Monocyte chemoattractant protein-1 (MCP-1)/CCL2 is a chemokine regulating the recruitment of monocytes into sites of inflammation and cancer. MCP-1 can be produced by a variety of cell types, such as macrophages, neutrophils, fibroblasts, endothelial cells, and epithelial cells. Notably, macrophages produce high levels of MCP-1 in response to proinflammatory stimuli in vitro, leading to the hyp...

Journal: :American journal of physiology. Regulatory, integrative and comparative physiology 2007
Michael Frink Ailing Lu Bjoern M Thobe Ya-Ching Hsieh Mashkoor A Choudhry Martin G Schwacha Steven L Kunkel Irshad H Chaudry

Leukocyte infiltration, mediated by chemokines, is a key step in the development of organ dysfunction. Lung and liver neutrophil infiltration following trauma-hemorrhage is associated with upregulation of monocyte chemoattractant protein-1 (MCP-1). Because MCP-1 is not a major attractant for neutrophils, we hypothesized that MCP-1 influences neutrophil infiltration via regulation of keratinocyt...

Journal: :Journal of the American Society of Nephrology : JASN 2011
Raj Munshi Ali Johnson Edward D Siew T Alp Ikizler Lorraine B Ware Mark M Wurfel Jonathan Himmelfarb Richard A Zager

Monocyte chemoattractant protein 1 (MCP-1) mediates acute ischemic and toxic kidney injury, but whether this can be used as a biomarker of acute kidney injury (AKI) is unknown. We obtained kidney and urine samples from mice with intrarenal (maleate), prerenal (endotoxemia), or postrenal (ureteral obstruction) injury. We also studied the independent effects of uremia without concomitant kidney i...

Journal: :Infection and immunity 1998
Y Lin J Gong M Zhang W Xue P F Barnes

To investigate the role of monocyte chemoattractant protein 1 (MCP-1) in the immune response to Mycobacterium tuberculosis, we studied MCP-1 production in tuberculosis patients. CD14+ blood monocytes from tuberculosis patients spontaneously expressed higher levels of MCP-1 mRNA and protein than CD14+ monocytes from healthy tuberculin reactors. MCP-1 production in lymph nodes from tuberculosis p...

Journal: :International Immunopharmacology 2021

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