BACKGROUND Selective Alzheimer Disease Indicator-1 (or Seladin-1) is a multifunctional protein first discovered by downregulation of its expression in Alzheimer's disease. Interestingly, the expression of this protein is upregulated in several cancers, including primary bladder cancer. However, its role in cancer formation has yet to be discovered. Goniothalamin is a natural product that has be...

Presenilin 1 and 2 are 2 highly homologous genes involved in familial Alzheimer disease. While more than 100 mutations in presenilin 1 are known to segregate with the disease in familial Alzheimer disease, only 9 mutations of presenilin 2 have been identified to date. We report the clinical and neuropathological phenotype of FLO10, the large Italian Alzheimer kindred associated with methionine ...

background and objective: alzheimer’s disease (ad) is a neurodegenerative disorder specified by deposition of b-amyloid (ab) and neuronal loss that leads to learning and memory disturbances. one of the most important causes of ad is glutamate-dependent excitotoxicity in brain regions that is vulnerable to ad. according to previous reported results, it was revealed that riluzole, as a glutamate ...

alzheimer's disease (ad) is the most common form of neurodegenerative disorders. memory loss in an alert person and impairment in the function of language, attention, perception, judgment or problem solving can occur in patients with ad. however, there are some medications in order to delay the debilitating aspects of the disease; but unfortunately, scientists could not found approaches to...

background: alzheimer’s disease (ad) is one of the most important neurodegenerative disorder. anti‑cyclic citrullinated peptide (anti‑ccp) may all be involved in the development of vascular disease such as ad. the aim of this study is detection of seropositivity for anti‑ccp antibody in ad patients. methods: in our study, 30 patients with ad and 29 healthy controls (age and‑sex matched) were re...

Objectives: Preferences of both Alzheimer patients and their spouse caregivers are related to a willingness-to-pay (WTP) measure which is used to test for the presence of mutual (rather than the conventional one-way) altruism. Methods: Identical contingent valuation interviews were conducted in 2000 2002 for 126 Alzheimer patients and their caregiving spouses living in the Zurich metropolitan a...

Public availability of automated methods for prediction of protein structure from sequence greatly benefits the community of 'wet-laboratory' biologists. Their reliability is assessed regularly on behalf of newly solved crystal and NMR structures, most prominently through the so-called CAFASP-experiments [1], and seems to be increasing on the whole. Clearly, however, the degree of confidence ac...

nowadays, air pollution is one of the major problems in developed and developing countries. in recent years, effects of air pollution on neuroinflammatory diseases such as alzheimer disease and parkinson disease have been studied. researches on polluted cities citizens indicate increasing in central nervous system (cns) inflammatory factors in comparison with clean cities; also air pollution ex...

dietary notifications have been introduced recently for alzheimer disease (ad). in iranian old medical manuscripts, there are some nutritional recommendations related to nesyan (ad equivalent). the aim of this article was to compare dietary recommendations of iranian traditional medicine (itm) with novel medical outcomes.1) searching for dietary recommendations and abstinences described in itm ...