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Abnormal microRNA (miRNA) expression profiles have recently been associated with sporadic pituitary adenomas, suggesting that miRNAs can contribute to tumor formation; miRNAs are small noncoding RNAs that inhibit posttranscriptional expression of target mRNAs by binding to target sequences usually located in the 3'-UTR. In this study, we investigated the role played by miR-107, a miRNA associat...
Metastasis is themajor cause of poor prognosis in colorectal cancer (CRC), and increasing evidence supports the contribution ofmiRNAs to cancer progression. Here, we found that high expression ofmiR-103 andmiR-107 (miR-103/107) was associated with metastasis potential of CRC cell lines and poor prognosis in patients with CRC. We showed that miR-103/107 targeted the known metastasis suppressors ...
IntroductionAccurate diagnosis of chikungunya (CHIK) is essential for effective disease management and surveillance. In a cohort febrile Congolese patients, available diagnostic methods widely used in CHIK were evaluated. addition, plasma cytokines quantified patients those coinfected with malaria compared healthy controls.MethodsBetween June November 2019, total 107 suspected subjected to diff...
Semen harbors amyloid fibrils formed by proteolytic fragments of prostatic acid phosphatase (PAP248-286 and PAP85-120) and semenogelins (SEM1 and SEM2) that potently enhance HIV infectivity. Amyloid but not soluble forms of these peptides enhance HIV infection. Thus, agents that remodel these amyloid fibrils could prevent HIV transmission. Here, we confirm that the green tea polyphenol, epigall...
BACKGROUND The aim of the study was to explore the effects of microRNA-107 (miR-107) by targeting Dkk-1 on osteosarcoma (OS) via the Wnt/β-catenin signaling pathway. METHODS OS and adjacent tissues were collected from 67 patients diagnosed with OS. Expressions of miR-107, Dkk-1, LRP5, β-catenin, and c-Myc were detected by the quantitative real-time polymerase chain reaction (qRT-PCR) and West...
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