Draft genome sequences of Aspergillus fumigatus strains (ISSFT-021 and IF1SW-F4), opportunistic pathogens isolated from the International Space Station (ISS), were assembled to facilitate investigations of the nature of the virulence characteristics of the ISS strains to other clinical strains isolated on Earth.

Corresponding author: Zhenchi Sang, Department of Cardiology, Pu Tuo Hospital, Shanghai University of Traditional Chinese Medicine, 164 LanXi Road, 200062 Shanghai, China, phone: +86 021 62572723, e-mail: [email protected] Received: 10.03.2015, accepted: 14.03.2015. Acute two-vessel occlusion due to simultaneous very late stent thrombosis following sirolimus-eluting stent implantation: a case repo...

1Department of Communicable Disease Control and Prevention, Jämtland County Council, Östersund, Sweden; 2Department of Clinical Microbiology, Unit of Clinical Research CenterÖstersund, Umeå University, Umeå, Sweden; 3Centre of Registers in Northern Sweden, Umeå University, Umeå, Sweden; 4Swedish Health Care Direct 1177, Jämtland County Council, Östersund, Sweden; 5Department of Clinical Microbi...

The concurrent targeting of critical nodes along key signaling pathways with molecularly targeted agents is a rational antitumor strategy, which has had varying degrees of success. Combinatorial challenges include overcoming synergistic toxicities and establishing whether combinations are truly active, to make "go, no-go" decisions to proceed to later phase trials. Clin Cancer Res; 23(5); 1123-...

T. Karuppanapandian1*, T. Karuppudurai2, P. B. Sinha1, A. M. K. Haniya3 and K. Manoharan1 1Department of Plant Sciences/2Department of Animal Behaviour and Physiology, Centre of Potential in Genomic Sciences, School of Biological Sciences, Madurai Kamaraj University, Madurai-625 021, India 3Department of Biotechnology, Srimad Andavan Arts & Science College, Thiruvanaikoil, Tiruchirappalli-620 0...

From the Hematology-Oncology Division, Department of Medicine, New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts 021 I1, the *Department of Pathology, New York University, New York, 10016, the *Department of Biochemistry and Pharmacology, Tufts University School of Medicine, and the ~Departments of Microbiology, Human Genetics and Development, and Neurology,...

This nested case-control study examined relationships between MDR1, CYP2B6, and CYP3A4 variants and hepatotoxicity during antiretroviral therapy with either efavirenz- or nevirapine-containing regimens. Decreased risk of hepatotoxicity was associated with MDR1 3435C-->T (odds ratio, 0.254; P=.021). An interaction between MDR1 and hepatitis B surface antigen status predicted risk with 82% accura...