The background of Paul E. Meehl’s work on clinical versus statistical prediction is reviewed, with detailed analyses of his arguments. Meehl’s four main contributions were the following: (a) he put the question, of whether clinical or statistical combinations of psychological data yielded better predictions, at center stage in applied psychology; (b) he convincingly argued, against an array of ...

TABLE OF CONTENTS INTRODUCTION: LAWS TARGETING PRICE DISCRIMINATION .............. 1237 I. ECONOMIC CONCEPTIONS OF PRICE DISCRIMINATION: A BRIEF REVIEW ..................................................................... 1239 A. Price Discrimination, Defined .......................................... 1239 B. Arbitrage, Market Power, and Price Discrimination ........ 1243 C. Price Discriminatio...

1 2 3 4 5 6 7 8 Editorial focus: 9 10 ACTH action on podocytes: mystery solved? 11 12 13 Paolo Cravedi and Kirk N Campbell 14 15 Division of Nephrology, Icahn School of Medicine at Mount Sinai, New York, New York 16 17 18 Running title: Melanocortins and podocytes 19 20 21 22 23 24 25 Word count: 947 26 27 28 29 30 31 32 33 34 35 Correspondence to: 36 Kirk N Campbell, MD 37 Division of Nephrolo...

BACKGROUND While smoking is the major cause of chronic obstructive pulmonary disease (COPD), occupational exposures to vapors, gases, dusts, and fumes (VGDF) increase COPD risk. This case-control study estimated the risk of COPD attributable to occupational exposures among construction workers. METHODS The study population included 834 cases and 1243 controls participating in a national medic...

for the treatment of emphysema study. Chest 2006; 130: 1334–1345. 11 Paul CC, Mahrer S, Tolbert M, et al. Changing the differentiation program of hematopoietic cells: retinoic acid-induced shift of eosinophil-committed cells to neutrophils. Blood 1995; 86: 3737–3744. 12 Viglio S, Annovazzi L, Luisetti M, et al. Progress in the methodological strategies for the detection in real samples of desmo...

We performed a randomised, crossover study to investigate the effects of intravenous sedation on grip strength and bite force. Twenty male volunteers received a bolus intravenous injection of midazolam (0.02 mg.kg(-1)) together with a 30-min propofol infusion designed to achieve an effect-site concentration of 1.0 μg.ml(-1). Observed variables included bispectral index, observer's assessment of...

The gene myogenin encodes a helix-loop-helix protein whose function is critical to the integrity of the mammalian myogenic cascade. In vitro, the expression of this gene immediately precedes terminal differentiation, as measured by the synthesis of those proteins that make up the contractile apparatus. However, during mammalian development, expression of myogenin and the appearance of sarcomere...

22:1-15. 8. Thomas TC, Rollins SA, Rother RP, et al. Inhibition of complement activity by humanized anti-C5 antibody and single-chain Fv. Mol Immunol. 1996;33:13891401. 9. Rother RP, Rollins SA, Mojcik CF, Brodsky RA, Bell L. Discovery and development of the complement inhibitor eculizumab for the treatment of paroxysmal nocturnal hemoglobinuria. Nat Biotechnol. 2007;25:1256-1264. 10. Hillmen P...

Recently, we demonstrated that a radio-frequency-free electromagnetostatic (rf-free EMS) cell could be retrofitted into a triple quad mass spectrometer to allow electron-capture dissociation (ECD) without the aid of cooling gas or phase-specific electron injection into the cell (Voinov et al., Rapid Commun Mass Spectrom 22, 3087-3088, 2008; Voinov et al., Anal Chem 81, 1238-1243, 2009). Subsequ...