O R IG IN A L A R T IC L E Alexandre Rodrigues Guerzoni Érika Cristina Pavarino-Bertelli Moacir Fernandes de Godoy

3,4-Methylenedioxymethamphetamine (MDMA) is a widely abused illicit drug that can cause severe and even fatal adverse effects. However, interest remains for its possible clinical applications in posttraumatic stress disorder and anxiety treatment. Preclinical studies to determine MDMA’s safety are needed. We evaluated MDMA’s pharmacokinetics and metabolism in male rats receiving 2.5, 5, and 10 ...

O R IG IN A L A R T IC L E INTRODUCTION Gastroesophageal refl ux disease (GERD) in infancy presents significantly greater incidence in the population with associated neurological disease. There is a consensus that multifactorial events are involved in its etiopathogenesis, which makes it diffi cult to evaluate the results from treatment and to obtain adequate uniformity regarding the most appro...

Sao Paulo Med J. 2007;125(6):333-7. O R IG IN A L A R T IC L E Mauro Karnikowski

O R IG IN A L A R T IC L E INTRODUCTION Adequate postoperative analgesia is considered to be a major key for reducing pul monary morbidity and improving the outcome. Thoracic epidural anesthesia (TEA) has been proposed as a reliable analgesic method following thoracic surgery. Most of these benefi ts, however, relate to the postoperative or to the so-called perioperative period. Some case repor...

Sao Paulo Med J. 2007;125(5):265-9. O R IG IN A L A R T IC L E Míriam Raquel Diniz Zanetti Rodrigo de Aquino Castro

The suppression of hepatic cytochrome P450 (P450) expression during inflammatory and infectious diseases and the relief of this suppression by successful disease treatment have been previously demonstrated to impact drug disposition. To address this clinically relevant phenomenon preclinically, the effect of proinflammatory cytokines on P450 isoenzymes in human hepatocytes has been examined by ...

Sao Paulo Med J. 2007;125(5):286-8. R E V IE W A R T IC L E Komal Bhatia

CONTEXT AND OBJECTIVE: Postoperative infections should be detected earlier. We investigated the effi cacy of the National Nosocomial Infection Surveillance (NNIS) score, interleukin-6 (IL-6) and various acute-phase proteins for predicting postoperative infections. DESIGN AND SETTING: Case series study at the Júlio Müller University Hospital. METHODS: Thirty-two patients who underwent major gast...

Sao Paulo Med J. 2007;125(4):237-41. O R IG IN A L A R T IC L E Domingos Dias Cicarelli Joaquim Edson Vieira Fábio Ely Martins Benseñor Early dexamethasone treatment for septic shock patients: a prospective randomized clinical trial Surgical Intensive Care Unit, Anesthesia Division, Department of Surgery, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo (HC/FMUSP), São ...