نتایج جستجو برای: 126
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OBJECTIVE MicroRNA plays important roles in vascular biology, but the regulation of endothelial-specific microRNA is not well characterized. MicroRNA-126 (miR-126) is highly expressed in endothelial cells, and it regulates angiogenesis and vascular inflammation. Here we show that the transcription factors Ets-1 and Ets-2 regulate miR-126 expression. METHODS AND RESULTS A genomic region betwee...
Poor long-term patency of vein grafts remains an obstacle in coronary artery bypass grafting (CABG) surgery using an autologous saphenous vein graft. Recent studies have revealed that miR-126-3p promotes vascular integrity and angiogenesis. We aimed to identify the role of miR-126-3p in the setting of vein graft disease and investigate the value of miR-126-3p agomir as a future gene therapy in ...
MicroRNA-126 (miR-126) has been reported to be a tumor suppressor that targets CXCR4 in colorectal cancer (CRC) cells. This study investigated whether miR-126 has any prognostic impact in patients with CRC. MiR-126 and CXCR4 mRNA expression in 92 pairs of CRC and adjacent nontumorous tissues was examined using quantitative real-time PCR, and CXCR4 protein expression was assessed by immunohistoc...
Key Points • AngiomiR-126 is secreted from circulating CD34 cells and acts as a signaling mechanism of pro-angiogenic effects on endothelial cells, which is impaired in diabetes. Several peripheral blood mononuclear cell (PBMC)–derived cell populations can promote angiogenesis, and differences in CD34 or CD14 surface expression have been used to separate PBMC subpopulations in this respect. Ang...
Circulating microRNAs (miRNAs) may represent a potential noninvasive molecular biomarker for various pathological conditions. Moreover, the detection of circulating miRNAs can provide important novel disease-related information. In particular, inflammation-associated miR-155 and endothelial-enriched miR-126 are reported to be associated with vascular homeostasis. Vascular damage is a common eve...
Jin Zhu ([email protected]) Dingding Zhang ([email protected]) Fengxia Wu ([email protected]) Xiaoqi Liu ([email protected]) Lijun Wu ([email protected]) Bin Zhou ([email protected]) JIanping Liu ([email protected]) Fang Lu ([email protected]) Jian Liu ([email protected]) Ruijun Luo ([email protected]) Wubin Long ([email protected]) Minghui Yang ([email protected]) Shi Ma (ms1516@12...
OBJECTIVE miR-126, the miRNA considered to be specially expressed in endothelial cells and hematopoietic progenitor cells, is strongly associated with angiogenesis. The purpose is to evaluate the role of miR-126 in hypoxia-induced angiogenesis and the possible mechanisms. METHODS The expression of miR-126 was detected in hypoxia-treated RF/6A cells and diabetic retinas using real-time PCR. Th...
BACKGROUND MicroRNA-126 has been found to be consistently under-expressed in osteosarcoma tissues and cell lines compared with normal bone tissues and normal osteoblast cells, respectively. The purpose of the present study was to detect the expression levels of miR-126 in osteosarcoma patients and to further investigate the clinicopathological, and prognostic value of miR-126. METHODS We recr...
The authors summarise the concepts of hysteria, emphasizing the seminal contribution of Charcot to its study.
The effect of atrial natriuretic factor (ANF) on adenylate cyclase activity was studied in rat platelet membranes. ANF-(99-126)-, -(101-126)-, -(103-126)- and -(103-123)-peptide inhibited adenylate cyclase activity in a concentration-dependent manner with an order of potency of ANF-(103-123)-peptide greater than ANF-(99-126)-peptide greater than ANF-(101-126)-peptide greater than ANF-(103-126)-...
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