This article reports changes in the striatal non-synaptic mitochondrial proteome of DJ-1, Parkin, and PINK1 knockout (KO) rats at 3 months of age. DJ-1, Parkin, and PINK1 mutations cause autosomal-recessive parkinsonism. It is thought that loss of function of these proteins contributes to the onset and pathogenesis of Parkinson׳s disease (PD). As DJ-1, Parkin, and PINK1 have functions in the re...

New facets to Knudson's [corrected] "two-hit" hypothesis have been proposed recently in relation to adenomatous polyposis coli (APC): protein inactivation may be selected weakly, and the two hits may be interdependent. We reviewed published data on 165 sporadic and 102 familial adenomatous polyposis-associated colorectal tumors with two characterized mutations. Using a Poisson model, we redefin...

Institute of Plant Molecular Biology, Centre National de la Recherche Scientifique Unité Propre de Recherche 2357 (R.H., B.B., H.R., C.G., J.I., J.-F.G., D.W.-R.), Institute for Advanced Study (H.R., D.W.-R.), Laboratoire de Chimie Organique Synthétique, Institut de Chimie, Centre National de la Recherche Scientifique Unité Mixte de Recherche 7177 (L.M., M.M.), and Plateforme d’Analyses pour la...

© 2012 The Authors. doi: 10.2340/00015555-1281 Journal Compilation © 2012 Acta Dermato-Venereologica. ISSN 0001-5555 Glomus tumours are distinctive neoplasms composed of cells resembling the modified smooth muscle cells of the normal glomus body (a specialized form of arteriovenous anastomosis involved in thermal and baroregulation) (1, 2). Vascular tumours with glomus cell morphology occur in ...

INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1253 R I. EXPANSION OF THE CONCEPTIONS . . . . . . . . . . . . . . . . . . . . . . . . 1256 R A. The Medical Conception . . . . . . . . . . . . . . . . . . . . . . . . . . . 1256 R B. The Educational Conception . . . . . . . . . . . . . . . . . . . . . . . 1259 R C. The Neurodiversity ...