A [2+2] cycloaddition reaction has been observed in a number of solids. The cyclobutane ring in a photodimerized material can be cleaved into olefins by UV light and heat. The high thermal stability of the metal-organic salt K2SDC (H2SDC = 4,4'-stilbenedicarboxylic acid) has been successfully utilized to investigate the reversible cleavage of a cyclobutane ring. The two polymorphs of K2SDC unde...

BACKGROUND Methylmalonic acid (MMA) is a dicarboxylic acid whose concentration can be increased in blood and urine in patients with an inborn error of metabolism or vitamin B(12) deficiency. We developed a method for the selective analysis of dicarboxylic acids that exploits the high specificity of tandem mass spectrometry (MS/MS) and the substantial difference in fragmentation patterns of the ...

A one-pot synthesis of 2,6-dibromodithieno[3,2-b;2',3'-d]thiophene (dibromo-DTT, 4) was developed. A key step was bromodecarboxylation of DTT-2,6-dicarboxylic acid, obtained by saponification of the diester 1. The donor-acceptor dye DAHTDTT (13), based on a central 2,6-bis[2'-(3'-hexylthienyl)]dithieno[3,2-b;2',3'-d]thiophene core (9), was prepared and incorporated in a dye-sensitized solar cel...

The title compound, (C(13)H(28)N(2))(2)[Zn(2)(C(8)H(4)O(4))Cl(6)]·4H(2)O, was prepared by the reaction of ZnCl(2)·6H(2)O, benzene-1,4-dicarboxylic acid and 4,4'-diamino-dicyclo-hexyl-methane in methanol. The [Zn(2)Cl(6)(C(8)H(4)O(4))](4-) anions lie on centres of inversion and comprise two ZnCl(3) groups bridged by benzene-1,4-dicarboxyl-ate. In addition to N-H⋯Cl and N-H⋯O hydrogen bonds betwe...

Medium-chain acyl-CoA dehydrogenase (MCAD) deficiency is the most frequently described metabolic disorder of fatty acid oxidation in humans. Acute episodes are usually characterized biochemically by the appearance of nonketotic dicarboxylic aciduria. In addition, other abnormal metabolites, such as suberylglycine, n-hexanoylglycine, 3-phenylpropionylglycine, and octanoylcarnitine, are excreted ...

A new proton transfer compound, formulated as (Hamp-6-pic)(Hpyzd) ∙H2O (1), has been synthesized from the reaction of pyrazine-2,3-dicarboxylic acid (H2pyzd)  and 2-amino-6-methyl pyridine (amp-6-pic), in 1:1 molar ratio. Extensive O−H×××O, N−H×××N and O−H×××O hydrogen bonds involving (Hamp-6-pic)+ cation, (Hpyzd)- anion and co-crystal water molecule٫ static electronic٫ and π…π stacking interac...

A range of highly substituted tetrahydropyrans have been prepared by reaction of a donor-acceptor cyclobutane, where the donor is a metal-alkyne complex, with an aldehyde under Lewis acid conditions.

A pair of bpe-H(+) ligands in a zwitter-ionic complex undergoes photochemical cycloaddition quantitatively accompanied by proton transfer and the cyclobutane ring isomerizes slowly in solution to two more isomers, catalyzed by CF(3)CO(2)H acid.

Esterification of inorganic phosphate accompanies the oxidation of succinic acid by cell-free extracts of E. coli. Inorganic phosphate appears to be an essential requirement for the dehydrogenation of the C(4)-dicarboxylic acid.

Carboxyl methyltransferase (CMT) enzymes catalyse the biomethylation of carboxylic acids under aqueous conditions and have potential for use in synthetic enzyme cascades. Herein we report that FtpM from Aspergillus fumigatus can methylate a broad range aromatic mono- dicarboxylic good to excellent conversions. The shows high regioselectivity on its natural substrate fumaryl-l-tyrosine, trans, t...