A new series of 2-substituted-5-[2-(2-halobenzyloxy)phenyl]-1,3,4-oxadiazoles was designed and synthesized as anticonvulsant agents. Electroshock and pentylenetetrazole-induced lethal convulsion tests showed that the introduction of an amino group at position 2 of 1,3,4-oxadiazole ring and a fluoro substituent at ortho position of benzyloxy moiety had the best anticonvulsant activity. Our resul...

An oxadiazole derivative with functional groups favouring its adsorption on copper surface, namely 5-(4-pyridyl)-1,3,4-oxadiazole-2-thiol, has been explored as potential inhibitor of corrosion in 3.5 wt.% NaCl. Electrochemical evaluation by electrochemical impedance spectroscopy, potentiodynamic polarization and SVET reveals high inhibition efficiencies. Surface microscopy inspection spectrosco...

As a part of our ongoing research in the exploration of novel antimicrobial agents, we report herein novel synthesis of hybrid molecules 4-methyl-7-(2-oxo-2-(5-(substitutedthio)-1,3,4oxadiazol-2-yl)ethoxy)-2H-chromen-2-ones and 4-substitutedbenzylidene-3-methyl-1-(2-((4methyl-2-oxo-2H-chromen-7-yl)oxy)acetyl)-1H-pyrazol-5(4H)-ones by combining coumarin ring with 1,3,4-oxadiazole and pyrazole sc...

In the title compound, C(18)H(13)BrN(4)O(3)S(3), the tetra-hydro-pyridine ring adopts a half-chair conformation with the central methyl-ene-C atom of the NCH(2)CH(2) unit at the flap. The dihedral angles between the tetra-hydro-pyridine ring and the pyridine and two thio-phene rings are 69.34 (13) 5.66 (13) and 68.63 (13)°, respectively, while the dihedral angle between the 1,3,4-oxadiazole and...

A structure-property study across a series of donor-acceptor-donor structures composed of mono- and bi-(1,3,4-oxadiazole) units symmetrically substituted with alkyl functionalized bi-, ter- and quaterthiophene segments is presented. Synthetically tailoring the ratio of electron-withdrawing 1,3,4-oxadiazole to electron-releasing thiophene units and their alkyl grafting pattern permitted us to sc...

the glycosylation of 1,3,4-oxadiazole-2-thiones has been performed with peracetylated β-pyranosyl bromide in the presence of potassium carbonate. deprotection of acetylated thioglycosides was necessary for increasing their antibacterial effects. the structure of nucleosides were confirmed by 1h nmr, 13c nmr and hrms. the anomeric protons of nucleosides c1–4 were assigned to the doublet, confirm...

the imine intermediate generated by the addition of primary amine to the cinnamaldehyde is trapped by the n-isocyaniminotriphenylphosphorane (ph3pnnc) and a carboxylic acid, and leads to the formation of the corresponding iminophosphorane intermediate. the 1,3,4-oxadiazole derivatives are formed via intramolecular aza-wittig reaction of the iminophosphorane intermediate. the reactions were comp...

1,3,4-oxadiazole derivatives constitute a group of biologically important compounds that have been used as analgesic, anti-inflammatory, antibacterial, antifungal, antispasmodic, or psychotropic drugs in addition to their role plant growth regulation and monoamine oxidase inhibition. This study focused on the use microwaves synthesis oxadiazole containing thiazolidinediones, which are promising...

A series of biaxial V-shaped, shape-persistent molecules has been synthesised by stepwise coupling of phenylene ethynylene arms to an oxadiazole bending unit. Studies of their thermotropic nematic phases point to phase biaxiality.