a new, high yielding method for the preparation of vasicinone (7) is described. reaction of 2-nitrobenzoic acid with n, n¢-carbonyldiimidazole followed by 2-pyrrolidinone gave 1-(2-nitrobenzoyl)pyrrolidine-2-one (3). reduction of the latter with 10% pd-c afforded deoxyvasicinone (4). reaction of deoxyvasicinone (4) with bromine yielded monobromo-deoxyvasicinone (5). exchange of bromine of 5 wit...

BACKGROUND Ankle distraction arthroplasty is one option for the treatment of severe ankle arthritis in young patients. The outcomes and factors predicting success in distraction arthroplasty are poorly understood. METHODS From January 2011 to May 2015, 16 patients who had undergone ankle distraction arthroplasty for ankle arthritis were operated, including six males and ten females. All patie...

an experiment was conducted to evaluate the effect of dietary crude protein and lysine levels on quality and quantity of egg production. fifteen diets consisted of 3 levels of protein (14, 15 and 16%) and 5 levels of lysine (0.71, 0.74, 0.77, 0.80 and 0.83 %) in a 35 factorial arrangement were provided. each diet was randomly fed to 4 replicates of 12 birds, during four periods of 4 weeks (28-...

Guidance on effective interventions for disruptive behavior in young children with autism spectrum disorders (ASDs) is limited. We present feasibility and initial efficacy data on a structured parent training program for 16 children (ages 3-6) with ASD and disruptive behavior. The 6-month intervention included 11 Core and up to 2 Optional sessions. The program was acceptable to parents as evide...

Benzodiazepines are among the most commonly prescribed medications due to their therapeutic efficacy in reducing anxiety and inducing sleep. Consequently, they have been widely employed in the pharmacological treatment of several disorders. Nevertheless, few studies have analyzed the effects of bromazepam in electroencephalographic activity (EEG). The present study aimed at investigating the mo...

Dekai Wu The Hong Kong University of Science and Technology 16.

In recent years, the convergence in sensing environments and pervasive computing has opened a scope for human activity recognition research. In this paper, we form populations from smartphone accelerometer and gyroscope sensor training-based data for Human Activity Recognition (HAR). In the same vein, we described in this work an Activity Recognition database, assembled from the recorded activi...

nantly target HIV proteases 1 and 2, it is also known that part of their efficacy is due to selective inhibition of the proteasome. The pathogenicity of high-risk human papilloma virus (HPV) is dependent on expression of viral E6 proteins which inappropriately activate the 26S proteasome to degrade p53 and other cellular proteins that are detrimental to viral replication. Comparison of the abil...