17-β-hydroxysteroid dehydrogenase type 3 (17β-HSD3) is an important enzyme involved in the final steps of androgen synthesis and is required for the development of normal male external genitalia. 46,XY individuals with deficiency of this enzyme present a wide clinical spectrum from a female appearance of the external genitalia through ambiguous genitalia to a predominantly male genitalia with m...

O ácido 6α,7β-di-hidroxivouacapan-17β-óico (1) e o 6α,7β-di-hidroxivouacapan-17β-oato de metila (2) são produtos naturais isolados do extrato hexânico de frutos de Pterodon polygalaeflorus Benth. Este trabalho descreve a preparação e caracterização por espectroscopias no infravermelho, de ressonância magnética nuclear e por análise elementar do derivado inédito 6α,7βtiocarbonildioxivouacapan-17...

Safety of milk can decline because high concentrations steroid hormones like 17β-estradiol, which is associated with the development some oncological diseases and reproductive disorders. We studied effects thermal processing raw technologies production butter yogurt on concentration 17β-estradiol. For this purpose, we determined amount 17β-estradiol in milk, after pasteurization under different...

Introduction: Estradiol is a neuroactive steroid, which is found in several brain areas such as locus coeruleus (LC). Estradiol modulates nociception by binding to its receptors and also by allosteric interaction with other membranebound receptors like glutamate and GABAA receptors. LC is involved in noradrenergic descending pain modulation. Methods: In order to study the effect of 17β-estra...

This study demonstrates the application feasibility of electrochemical impedance spectroscopy (EIS) in measuring estrogen (17β-estradiol) in gas phase. The present biosensor gives a linear response (R2 = 0.999) for 17β-estradiol vapor concentration from 3.7 ng/L to 3.7 × 10-4 ng/L with a limit of detection (3.7 × 10-4 ng/L). The results show that the fabricated biosensor demonstrates better det...

previous studies have demonstrated the potential of monotherapy with either mesenchymal stem cells (mscs) or estrogen in autoimmune and cuprizone models of multiple sclerosis (ms). the aim of this study was to examine the effects of co-administration of 17β-estradiol (e2) and adipose-derived mesenchymal stem cells (adscs) on remyelination of corpus callosum axons in a cuprizone model of ms. for...

The title compound, C(20)H(26)O(6)S, synthesized by the reaction of 3-O-meth-oxy-methyl-16β-epiestriol and sulfonyl-diimidazole, is composed of a 3-meth-oxy-methyl group connected via two O atoms to a 16,17-O-sulfuryl-16-epiestriol group. In the crystal, weak inter-molecular C-H⋯O hydrogen bonds link the mol-ecules into [001] chains.

17β-estradiol modulates the activity of D2 receptors in regulation food intake and body weight. The functional lack postmenopausal women could create a dietary imbalance cause weight gain. This study aimed to better understand interferences that exist between 17β-estradiol, selection carbohydrate, fat protein consumption, as well their consequences on gain by using an animal model menopause. Ov...

Glabridin is an isoflavan from licorice root, which is a common component of herbal remedies used for treatment of menopausal symptoms. Past studies have shown that glabridin resulted in favorable outcome similar to 17β-estradiol (17β-E2), suggesting a possible role as an estrogen replacement therapy (ERT). This study aims to evaluate the estrogenic effect of glabridin in an in-vitro endometria...

Estrogen produces vasodilatation through the induction of nitric oxide synthase (NOS) in the endothelium, but there are many reports of endothelium-independent effects. In the present study, these processes were investigated in rat aortas isolated from ovariectomized rats. Long-term in vitro treatment with 17β-estradiol (10 nM for 24 h) in an organ culture system slightly reduced acetylcholine-...