Vitamin B1 (aneurin, thiamine) is a water-soluble vitamin necessary for the normal function of nervous system, visual system and heart part important enzymes in body. Thiamine enables use glucose, other carbohydrates proteins, supply energy to organism. The main sources thiamine are exogenous small amounts synthesized by microorganisms human intestinal microbiome. cannot accumulate body, so sig...

6,123,819 A * 9/2000 Peeters ....................... 204/452 6,361,958 B1 * 3/2002 Shieh et al. ................. 435/7.1 6,524,790 B1 * 2/2003 Kopf-Sill et al. .............. 435/6 6,585,939 B1 7/2003 Dapprich 6,599,436 B1 7/2003 Matzke et al. 6,613,512 B1 9/2003 Kopf-Sill et al. 6,649,358 B1 * 11/2003 Parce et al. .................. 435/7.2 6,699,665 B1 * 3/2004 Kim et al. ......................

Liver cancer is a major cause of premature death in many areas of Africa and Asia and its incidence is strongly correlated with exposure to aflatoxin B1 (AFB1). Because AFB1 requires metabolic activation to achieve a biological response, there is a need for detailed knowledge of the mechanism of activation to assess individual risk. We have carried out an extensive study using a total of 19 hum...

background premenstrual syndrome (pms) is a combination of physical, psychological and emotional symptoms that occur periodically before menstruation and disappear with the onset of menstruation. there are some therapeutic methods mostly according to the clinical trials that reduce the prevalence and intensity of symptoms of pms by unknown mechanisms. this study aimed to investigate the effects...

Background: Recently, some new nanobiosensors using different nanoparticles or microarray systems for detection of mycotoxins have been designed . However, rapid, sensitive and early detection of aflatoxicosis would be very helpful to distinguish high-risk persons. Objectives: We report a highly sensitive competitive immunoassay using magnetic/silica core shell as a signal intensifier for the d...

The AMP-activated protein kinase (AMPK) cascade is activated by an increase in the AMP/ATP ratio within the cell. AMPK is regulated allosterically by AMP and by reversible phosphorylation. Threonine-172 within the catalytic subunit (alpha) of AMPK (Thr(172)) was identified as the major site phosphorylated by the AMP-activated protein kinase kinase (AMPKK) in vitro. We have used site-directed mu...