BACKGROUND Vision and hearing impairments among elders are common, and cognitive impairment is a concern. This study assessed the association of vision and hearing impairments with cognitive impairment and mortality among long-term care recipients. METHODS Data of 1754 adults aged 65 or older were included in analysis from the Gujo City Long-Term Care Insurance Database in Japan for a mean fo...

Studies show that kidneys produce 2 ,3 -cAMP, 2 ,3 -cAMP is exported and metabolized to 2 -AMP and 3 -AMP, 2 -AMP and 3 -AMP are metabolized to adenosine, 2 ,3 -cAMP inhibits proliferation of preglomerular vascular smooth muscle cells (PGVSMCs) and glomerular mesangial cells (GMCs), and A2B (not A1, A2A, or A3) adenosine receptors mediate part of the antiproliferative effects of 2 ,3 -cAMP. The...

Rat vascular smooth muscle cells (VSMCs) from renal microvessels metabolize 2',3'-cAMP to 2'-AMP and 3'-AMP, and these AMPs are converted to adenosine that inhibits microvascular VSMC proliferation via A(2B) receptors. The goal of this study was to test whether this mechanism also exists in VSMCs from conduit arteries and whether it is similarly expressed in human vs. rat VSMCs. Incubation of r...

Serendipidade é um termo frequentemente usado em contexto de investigação e descobertas científicas. Trata-se anglicismo recente no léxico português com o seguinte significado, segundo dicionário da Porto Editora: 1 — Aptidão atrair a si acontecimentos favoráveis maneira fortuita; dom fazer boas por acaso: 2 Acontecimento favorável que se produz acaso feliz; descoberta acidental1. O serendipity...