Brazil 13 14 #Corresponding author: Leonardo JM Carvalho, La Jolla Bioengineering Institute, 3535 15 General Atomics Court, Suite 210, San Diego, CA, 92121, USA, Telephone:1−858−456−7500, 16 Fax:1−858−456−7540, Email: [email protected] 17 18 AAC Accepts, published online ahead of print on 26 August 2013 Antimicrob. Agents Chemother. doi:10.1128/AAC.00488-13 Copyright © 2013, American Society f...

Here, we describe a new mechanism by which glutamate (Glu) and trace metals reciprocally modulate activity of the Ca(v)2.3 channel by profoundly shifting its voltage-dependent gating. We show that zinc and copper, at physiologically relevant concentrations, occupy an extracellular binding site on the surface of Ca(v)2.3 and hold the threshold for activation of these channels in a depolarized vo...

The ability of CCKA antagonists to inhibit full and partial CCK agonists of the rat pancreatic acinar cell CCKA receptor has been studied. When isolated rat pancreatic acini were superfused with CCK-8 (10 pM-1 nM) or CCK-4 (1 microM), an increase in [Ca2+]i signal was initiated. Concurrent superfusion of either L-364,718 (0.1 microM) or lorglumide (10 microM), chemically distinct, specific, pot...

The well known conjugate gradient algorithm (cg-algorithm), introduced by Hestenes & Stiefel, [1952] intended for real, symmetric, positive definite matrices works as well for complex matrices and has the same typical convergence behavior. It will also work, not generally, but in many cases for hermitean, but not necessarily positive definite matrices. We shall show, that the same behavior is s...

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925-Pos Novel Visualisation Techniques for Localisation Microscopy David Baddeley, Isuru D. Jayasinghe, Sabrina Roßberger, Mark B. Cannell, Christian Soeller. University of Auckland, Auckland, New Zealand. Localisation microscopy techniques based on localising single fluorophore molecules now routinely achieve accuracies better than 30 nm. Unlike conventional optical microscopy approaches, loca...

Isaac Chu, BA, MPH*, Federico Vaca, MD, MPH**, Sam Stratton, MD, MPH** Bharath Chakravarthy, MD**, Wirachin Hoonpongsimanont, MD**, Shahram Lotfipour, MD, MPH** *Western University of Health Sciences, College of Osteopathic Medicine of the Pacific, Pomona, CA **Department of Emergency Medicine, University of California Irvine, School of Medicine, Irvine, CA Correspondence: Shahram Lotfipour, MD...

PURPOSE To determine the conversion coefficients (CCs) from the dose-area product (DAP) value to effective dose in cone-beam CT. MATERIALS AND METHODS A CBCT scanner with four fields of view (FOV) was used. Using two exposure settings of the adult standard and low dose exposure, DAP values were measured with a DAP meter in C mode (200mm×179 mm), P mode (154 mm×154 mm), I mode (102 mm×102 mm),...