نتایج جستجو برای: 182
تعداد نتایج: 9355 فیلتر نتایج به سال:
Type 2 diabetes (T2D) is a prevalent disease that happens around the world and usually happens with insulin resistance. MicroRNAs (miRNAs) represented important roles in the suppression of gene expression and were proven to be related to human diseases. In this study, we used cynomolgus monkey fed with normal and high fatty diet (HFD), respectively, to analyze the miRNA expression profile in wh...
MicroRNAs are noncoding regulators of gene expression, which act by repressing protein translation and/or degrading mRNA. Many have been shown to drive tumorigenesis in cancer, but functional studies to understand their mode of action are typically limited to single-target genes. In this study, we use synthetic biotinylated miRNA to pull down endogenous targets of miR-182-5p. We identified more...
مقدمه: mirna ها مولکول های rna تک رشته ای غیرکدکننده به طول حدود 21 تا 23 نوکلئوتید هستند که ترجمه نمی شوند و در کنترل بیان ژن نقش مهمی دارند. آنها به عنوان انکوژن یا تومور ساپرسور نقش مهمی در بروز برخی سرطان ها دارند. در گزارشات مختلف mir-182 به عنوان آنکومیر در سرطان گردن رحم معرفی شده است که مانع از انجام آپوپتوز در سلول می گردد. هدف از مطالعه حاضر بررسی تأثیر antimir-182 در رده سلولی سرطانی...
The highly aggressive character of melanoma makes it an excellent model for probing the mechanisms underlying metastasis, which remains one of the most difficult challenges in treating cancer. We find that miR-182, member of a miRNA cluster in a chromosomal locus (7q31-34) frequently amplified in melanoma, is commonly up-regulated in human melanoma cell lines and tissue samples; this up-regulat...
Myocardial hypertrophy is an adaptive response to hemodynamic demands. Although angiogenesis is critical to support the increase in heart mass with matching blood supply, it may also promote a hypertrophic response. Previously, we showed that cardiac angiogenesis induced by placental growth factor (PlGF), promotes myocardial hypertrophy through the paracrine action of endothelium-derived NO, wh...
AMA Piechowicz P, Dunaj Janota A, Kołodziejczyk K, Dzierżanowski T. Non-pharmacological therapy options for chemotherapy-related cognitive impairment. Medycyna Paliatywna/Palliative Medicine. 2022;14(4):173-182. doi:10.5114/pm.2022.127038. APA Piechowicz, P., Dunaj, Janota, A., Kołodziejczyk, K., & Dzierżanowski, (2022). Medicine, 14(4), 173-182. https://doi.org/10.5114/pm.2022.127038 Chicago P...
JUNB, a subunit of the AP-1 transcription factor complex, mediates gene regulation in response to a plethora of extracellular stimuli. Previously, JUNB was shown to act as a critical positive regulator of blood vessel development and homeostasis as well as a negative regulator of proliferation, inflammation and tumour growth. Here, we demonstrate that the oncogenic miR-182 is a novel JUNB targe...
Purpose: This study aims to investigate preventability criteria of adverse drug reactions (ADRs) involving non-steroidal anti-inflammatory drugs (NSAIDs) by analyzing individual case safety reports (ICSRs) sent through Campania region (Italy) spontaneous reporting system from July 2012 to October 2016. Methods: For all the ICSRs that reported NSAIDs as suspected drug, a trained multidisciplinar...
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