. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 185 1. A Mechanistic Approach to Pain Management . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 187 1.1 Mechanisms of Pain . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ....

The reversible regulation of myosin light chain phosphatase (MLCP) in response to agonist stimulation and cAMP/cGMP signals plays an important role in the regulation of smooth muscle (SM) tone. Here, we investigated the mechanism underlying the inhibition of MLCP induced by the phosphorylation of myosin phosphatase targeting subunit (MYPT1), a regulatory subunit of MLCP, at Thr-696 and Thr-853 ...

Previous experimental studies have demonstrated that MMPs (matrix metalloproteinases) contribute to LV (left ventricular) remodelling. We hypothesized that cardiac MMPs are activated in patients with AMI (acute myocardial infarction) and, if so, MMP production may be attenuated by statins (3-hydroxy-3-methylglutaryl-CoA reductase inhibitors) through their cardiovascular protective actions. We s...

In this paper we provide a Stone style duality for monotone semilattices by using the topological developed in S. Celani, L.J. González (Appl Categ Struct 28:853–875, 2020) together with description of their canonical extension. As an application obtain characterization congruences means lower-Vietoris-type topologies.

Parkinson's disease (PD) is an age‑associated neurodegenerative disorder characterized by the death of dopaminergic neurons in the substantia nigra pars compacta. Activation of 5'‑adenosine monophosphate‑activated protein kinase (AMPK) has been suggested to be associated with PD pathogenesis. The aim of the present study was to investigate the effects of the aberrant expression of microRNA‑185 ...

Mangaser et al, “Concurrent programming support for a multi-manipulator experiment on RIF’S”; 1989 IEEE International conference on robotics and automation, p. 853-859 vol. 2, 14-19 May 1989. Anderson, “Computer architectures for robot control: a comparison and a new processor delivering 20 real mflops”; 1989 IEEE International conference on robotics and automation, p. 1162-1167 vol. 2, 14-19 M...

BOOK REVIEWS Cancer Institute Unilaterally Issues New Restrictions on Mammography . . . . . . . 853 Battle to Legitimize Laetrile Continues Unabated . . . . . . . . . . . . . . . . . . 854 How the Swedes Live Well While Consuming Less Energy . . . . . . . . . . . . . 856 Smithsonian: "The Nation's Attic" Undergoing New Federal Scrutiny . . . . . . . 857 Warnke Stuck with Verification Task . . ....

Address reprint requests to Dr. Reto Krapf, Division of Nephroiogy, 1065 HSE, University of California, San Francisco, CA 94143. J. GEN. PSVSlOL. @ The Rockefeller University Press 9 0022-1295/87/12/0833/21 $2.00 833 Volume 90 December 1987 833-853 on July 2, 2017 jgp.rress.org D ow nladed fom 834 T H E JOURNAL OF GENERAL PHYSIOLOGY 9 VOLUME 90 9 1987