The synthesis of C2-symmetrical bis(β-enamino-pyran-2,4-dione) derivative 3 connected via 1,6-hexylene linker was reported for the first time. X-ray structures and Hirshfeld studies new bis- β-enamino-pyran-2,4-dione along with two structurally related pyran-2,4-dione derivatives 2a,b were discussed. A comparative analysis different intermolecular contacts affecting crystal stability presented....

Six regioisomers associated with the tricyclic core of thiaplakortones A-D have been synthesized. Reaction of 1H-indole-4,7-dione and 1-tosyl-1H-indole-4,7-dione with 2-aminoethanesulfinic acid afforded a regioisomeric series, which was subsequently deprotected and oxidized to yield the tricyclic core scaffolds present in the thiaplakortones. All compounds were fully characterized using NMR and...

In the title compound, C(8)H(6)N(2)O(2), inter-molecular N-H⋯O hydrogen bonds involving the amine and carbonyl groups create centrosymmetric dimers between adjacent nearly coplanar mol-ecules. These dimers are further connected by weak N-H⋯O hydrogen bonds, forming a two-dimensional network. Mol-ecules are packed in the crystal structure with adjacent benzene and pyrimidine rings approximately ...

The CD and UV spectra of (2S)-2,2'-spirobi[2H-benz[e]indene]1,1'(3H,3'H)-dione (2) and (IR,I'S,2S)-I,I',3,3'-tetrahydro-2,2'-spirobi[2H -benz[e]indene]-I,I' -diyl diacetate (3) were theoretical1y calculated by the application of the Jt-electron SCF-CI-DV MO method. The shape of component CD and UV bands was approximated by method (A) of the Gaussian distribution, or by method (B) employing the ...

The synthesis of the new Co(II), Ni(II), Cu(II), Cd(II), Pd(II) and Pt(II) complexes with 1-methyllumazine (1-methylpteridine2,4(1H ,3H )-dione, MLM) and 1,6,7-trymethyllumazine (1,6,7-trimethylpteridine-2,4(1H ,3H )-dione, MLMD) is described. The coordination chemistry of these ligands have been investigated and an usual bidentate bonding mode through the N5 and O4 atoms is observed. These com...

Using methanesulfonic acid as a catalyst, a series of cyclododeceno[b]indene derivatives were synthesized by the cyclization of alpha-benzylcyclododecanones, which were prepared by the reactions of cyclododecanones with a variety of substituted benzyl chlorides or bromides using NaH as a base. Their structures were confirmed by mp, IR spectra, 1H-NMR, 13C-NMR, MS, and x-ray diffraction. The pre...

A series of 17 long-chain arylpiperazines containing bulky, complex imide systems (5,8-dimethyl-3b,9-epoxy-(3a,4,5,6,7,8,9,9a)-octahydro-1H-benzo[e]isoindole-1,3(2H)-dione or 4,9-diphenyl-4,9-epoxy-3a,4,9,9a-tetra-hydro-1H-benzo[f]isoindole-1,3(2H)-dione) was synthesized and evaluated for their affinity for serotonin 5-HT1A, 5-HT2A and dopamine D2 receptors. Most of the new compounds showed mod...