نتایج جستجو برای: 2 aminothiazole
تعداد نتایج: 2525278 فیلتر نتایج به سال:
Organic push–pull chromophoric system containing thiazole Schiff bases were synthesized from aminothiazole intermediate. These novel chromophores possessed excellent thermal and optical properties with complete transparency in the visible spectral region. Thermogravimetric analysis revealed that all dyes were thermally stable at temperatures above 300 C. The third-order nonlinear optical studie...
This paper discusses a rapid and sensitive method developed to determine trace levels of mercury in natural water samples by cold vapor atomic absorption spectrometry using a preconcentration system composed by mini-column packed with 100 mg of 2-aminothiazol modified silica gel (SiAT) coupled on-line with the spectrometer’s cold vapor generator system. The optimum preconcentration conditions a...
Because no drug exists that halts or even slows any neurodegenerative disease, developing effective therapeutics for any prion disorder is urgent. We recently reported two compounds (IND24 and IND81) with the 2-aminothiazole (2-AMT) chemical scaffold that almost doubled the incubation times in scrapie prion-infected, wild-type (wt) FVB mice when given in a liquid diet. Remarkably, oral prophyla...
attracted the attention of chemists, since they exhibit important biological activity in medicinal chemistry.1 As one example, they show very good antibacterial effects.2 Here, we report the crystal structure of the title compound, shown in Fig. 1. To a solution of 1.042 g (10 mmol) of N-ethyl thiourea in 50 mL of absolute ethanol, a solution of 2.645 g (10 mmol) of 1-mesityl-1-methyl-3-(2-chrl...
Alzheimer's disease (AD) is characterized pathologically by an abundance of extracellular neuritic plaques composed primarily of the 42-amino acid amyloid β peptide variant (Aβ42). In the majority of familial AD (FAD) cases, e.g., those harboring mutations in presenilin 1 (PS1), there is a relative increase in the levels of Aβ42 compared to the levels of Aβ40. We previously reported the charact...
Creutzfeldt-Jakob disease (CJD) is a rare but invariably fatal neurodegenerative disease caused by misfolding of an endogenous protein into an alternative pathogenic conformation. The details of protein misfolding and aggregation are not well understood nor are the mechanism(s) by which the aggregated protein confers cellular toxicity. While there is as yet no clear consensus about how best to ...
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