In current screening test for Down’s syndrome (namely maternal serum alpha-fetoprotein-AFPhuman chronic gonadotropinhCG-, unconjugated estriol plus maternal age) an elevated level of hCG is an important predictor of fetal aneuploidy (1). The positive predictive value of the multiple marker screening test is approximately 4.3% (2). Besides Down’s syndrome, triploidy, trophoblastic diseases, and ...

Studies in both patients and mice have been carried out using heterologous antibody directed at secreted products of tumors. In preliminary therapeutic studies in patients with drug-resistant choriocarcinoma and malignant teratoma, heterologous anti-human chorionic gonadotrophin (HCG) and anti-alpha-fetoprotein have been combined with continued cytotoxic chemotherapy. The results to date, altho...

A study was conducted to test the hypothesis that injecting Gonadotropin-releasing hormone (GnRH) concurrently with Prostaglandin F2 alpha (PGF(2α)) followed by an injection of human Chorionic Gonadotropin (hCG), would advance follicular growth to ovulation in Holstein heifers bearing a corpus luteum (CL). After manual examination of the CL, group 1 (PGF; n = 12) received an injection of PGF(2α...

OBJECTIVE The combination of mifepristone and misoprostol is an established method for induction of early first trimester abortion, but there is no consensus about the best evaluation of treatment outcome. We evaluate serum Angiopoietin-2 (Ang-2) and β human chorionic gonadotropin (β-hCG) in women who had undergone a medical abortion as markers of prolonged uterine bleeding (PUB). METHODS Pro...

Background: The existing gene annotation schemes generally classify genes into twolevels of parallel and unrelated homologous and/or orthologous gene groups, limiting our capabilities for gene function prediction at higher resolution. While homology and orthology are useful concepts for evolutionary studies of genes, they may not be the most appropriate ones for functional classification of gen...

BACKGROUND Hyperglycosylated human chorionic gonadotropin (hCG-h) contains larger and more complex carbohydrate chains than regular human chorionic gonadotropin (hCG). hCG-h is thought to be the major form of hCG produced by testicular cancers and it has been suggested to play a key role in tumor invasion, but studies on hCG-h in testicular cancer are limited. We studied whether serum hCG is hy...

Abstract Background Blood coagulation has been associated with ovulation and female infertility. In this study, the expression of tissue factor system was examined during in immature rats; correlation between ovarian hyperstimulation syndrome (OHSS) evaluated both rats human follicular fluids. Methods Ovaries were obtained at various times after chorionic gonadotropin (hCG) injection to investi...

I am disappointed that the recent Q&A article in Clinical Chemistry dealing with assays for human chorionic gonadotropin (hCG) did not mention that all commercial hCG assays in the US are FDA cleared only for the early detection of pregnancy (1 ). The current situation is very unsatisfactory, because these assays, with the knowledge of the manufacturers, are in widespread use for oncology. What...

BACKGROUND The contribution of the adrenal glands to the total circulating steroid pool in women is not well known. There is evidence that human adrenals express the LH receptor gene and that LH may affect adrenal androgen secretion. METHODS HCG stimulation tests (a single dose of 5000 IU i.m.) were performed in women at reproductive age (group 1, n = 6, age 21--39 years) before and after tre...