Selective inhibition of proinflammatory chemokines such as IL-8 is an important approach to combat inflammatory and infection diseases. Previous studies suggested that interaction of transcription factors NFkappaB repressing factor (NRF) and NFkappaB play a crucial role in activation of IL-8 gene expression. In a search for a specific inhibitor of IL-8 expression, we applied tandem affinity pur...

BACKGROUND Hyperglycemia is one of the most dangerous factors causing diabetic nephropathy. Salidroside is considered to have the effects of reducing oxidative stress damage and improving cell viability. This study was performed to investigate whether and how salidroside reduces high-glucose (HG)-induced apoptosis in mouse podocytes. MATERIAL AND METHODS We examined whether salidroside could de...

Nutrient-rich food (NRF) index scores are dietary quality indices based on nutrient density. We studied the design aspects involved in the development and validation of NRF index scores, using the Dutch consumption data and guidelines as an example. We evaluated fifteen NRF index scores against the Dutch Healthy Diet Index (DHD-index), a measure of adherence to the Dutch dietary guidelines, and...

UNLABELLED Angiography of patients with typical chest pain reveals normal epicardial coronary arteries in about 20%. Coronary flow reserve (CFR) determination is an elaborate, but helpful, task, as only the evidence of microvascular disease enables appropriate therapy. We prospectively evaluated the incidence of a dysfunctional microcirculation and searched for predictive parameters of a reduce...

This article contains supplemental Tables 1-2, and Figs. S1–S3. * This work was supported by a National Science Foundation (USA) grant (0726284) to DPSV, and the National Research Foundation of Korea (NRF) grants funded by the Korea government (MSIP) to Sookmyung MRC center (2011-00300074; C-I C) and to SK (NRF-2010-A0604C00031). 1 These authors contributed equally to this work. 2 To whom corre...

This study was designed to investigate whether hydrogen administration can produce neuroprotective effects and its related molecular mechanism after brain ischemia reperfusion in rats. 36 Sprague-Dawley rats were randomly divided into sham group, ischemia reperfusion group and ischemia reperfusion hydrogen therapy group. Brain ischemia reperfusion injury was induced by a 2-hour left middle cere...

Insufficient endogenous neurotrophin supply contributes to neurodegeneration. Meanwhile, neuronal injuries are also attributed to oxidative stress upon toxin exposure. Thus, reconstruction neurite extension and antioxidative stress are the potential strategies for ameliorating neuronal injuries. However, there is no well-defined therapeutic developed in this regard. In search of such therapeuti...

Vapor-liquid equilibrium in NH3-CO2-H2O system at high pressures has been studied. The UNIQUAC-NRF model for this system was extended by using the Goppert 4 maurer reported datas. Since the system contains molecules and ionic species the binary interaction parameters considered, where those are of molecule-molecule, molecule-ion and ion-ion types. These interaction parameters are taken as c...

Apoptosis is a component of cardiac remodeling following myocardial ischemia and infarction. MicroRNAs (miRNAs) are involved in regulating a range of cellular biological processes, including apoptosis, by regulating gene expression at the post-transcriptional level. Nuclear respiratory factor-1 (NRF-1) is a transcriptional activator of nuclear genes that encode a range of mitochondrial proteins...