D-tagatose is in development as a medication for the treatment of type 2 diabetes. The effect of oral D-tagatose on the absorption of D-fructose was assessed when co-administered in this study. In the pilot study, male Sprague-Dawley rats were fed C14 labeled fructose and glucose concomitantly to establish dose levels for the treatment group of rats fed C14 labeled fructose together with D-taga...

To determine the anticonvulsant activity of the leaf extract of Croton zambesicus in mice and rats, and in order to verify the traditional use of the plant in the treatment of epilepsy. The pentyleneterazole (PTZ) and the maximal electroshock seizure (MES) models were used for assessing the anticonvulsant effects of the aqueous leaf extract in mice and rats. In the PTZ test, the leaf extract ...

PURPOSE To describe an experimental model of cutaneous radiation injury in rabbits. METHODS On this study eight six-month-old New Zealand male rabbits, with an average weight of 2.5 kg were used. They were distributed in four groups (n=2 per group). The control group did not receive radiotherapy and the others received one radiotherapy session of 2000, 3000 and 4500 cGy, respectively. Photogr...

Thymol’s antimicrobial properties urged researchers to study its effect on animal performance and intestinal health in pigs. However, thymol has the characteristic sharp odor of thyme and a bitter, aromatic, and sometimes burning sensation which may elicit feeding aversions. The objectives in the current study were: (1) to determine the effect of dose of thymol and camphor on palatability and (...

BACKGROUND Currently available therapeutic options for thromboembolic disorders are often very expensive and are associated with unfavorable side effects. AIM To establish the anticoagulant effect and safety profile of an extract made from of the root bark of Pseudocedrela kotschyi (Schweinf.) Harms and the aerial part of Adenia cissampeloides (Planch. ex Hook.) Harms (PAE). MATERIALS AND M...

Two biochemically different rescue agents, citrovorum factor (CF) and thymidine-inosine-allopurinol (TIA), were compared in an attempt to identify the mechanism for the increased therapeutic index achieved with high-dose methotrexate (MTX) plus rescue. Both CF and TIA were capable of protecting mice from MTX dosages up to 2000 mg/kg. Treatment of L1210-bearing mice with 2000 mg/kg MTX plus CF o...

Prosopis africana (Guill and Perr) Taub fruit methanolic extract was tested for its antinociceptive properties. 4.2% w/w dry yield obtained after 48 hours of 80% methanol at room temperature during cold maceration. occasional shake every two hours. It had a golden brown color, sticky odorous, foamed as it dissolved in distilled water. In mice, the did not exhibit any acute hazardous effects stu...

n the past 2 decades, heart failure (HF) research has focused primarily on drugs and devices. In contrast, evidence remains scarce and mostly observational for dietary sodium restriction, 1–3 arguably the most widely recommended self-care measure for patients with HF. In recent studies, patients with HF consumed an average of 3600 to 4200 mg sodium daily by 24-hour urinary sodium excre-tion, 4 ...

objective: pinus eldarica (p. eldarica) is one of the most common pines in iran which has various bioactive constituents and different uses in traditional medicine. since there is no documented evidence for p. eldarica safety, the acute and sub-acute oral toxicities of hydroalcoholic extract of p. eldarica bark were investigated in male and female wistar rats in this study. materials and method...

The purpose of this experiment was to examine the physiological responses of adult cockatiels at maintenance to dietary vitamin A (VA) concentrations, and to identify concentrations associated with deficiency and toxicity. Adult cockatiels at maintenance (n = 22, 2-3 y of age) were fed a diet of 0, 600, 3000 or 30,000 microg VA/kg (0, 2000, 10,000 or 100,000 IU), and monitored for signs of VA d...