Monoclonal antibodies against soybean Bowman-Birk protease inhibitor (BBI) have been generated and used to detect and quantify BBI in foods, soybean germplasm, and animal tissues and fluids. The purpose of this study was to determine the recognition sites of two monoclonal antibodies to BBI (mAb 238 and mAb 217) in relation to the protease-inhibitory sites of BBI. The results showed that (1) th...

Ethanol-mediated inhibition of hepatic sirtuin 1 (SIRT1) plays a crucial role in the pathogenesis of alcoholic fatty liver disease. Here, we investigated the underlying mechanisms of this inhibition by identifying a new hepatic target of ethanol action, microRNA-217 (miR-217). The role of miR-217 in the regulation of the effects of ethanol was investigated in cultured mouse AML-12 hepatocytes a...

Calciphylaxis is a rare, highly morbid disease leading to vascular calcification and cutaneous necrosis, typically associated with end-stage renal (ESRD). While the pathogenesis risk factors of calciphylaxis are poorly understood, some cases in patients who had previously undergone gastric bypass have been reported. The objective this study report describe an association between nutritional def...

Long non-coding RNA HOTAIR was regarded as an oncogene in multiple cancers. Previous studies have shown that HOTAIR is involved in the proliferation and tumorigenesis of renal carcinoma cells, while microRNA (miR)-217 functions as a tumor suppressor in renal cell carcinoma (Rcc). However, the underlying molecular mechanism of HOTAIR in Rcc, especially in association with miR-217, has not been s...

We have isolated two alleles of a previously unidentified meiotic recombination gene, mei-217. Genetic analysis of these mutants shows that mei-217 is a typical "precondition" gene. The phenotypes of the mutants are meiosis specific. The strongest allele has <10% of the normal level of crossing over, and the residual events are distributed abnormally. We have used double mutant analysis to posi...

Osteosarcoma is the most common type of primary tumor of bone which mainly affects adolescents and young adults. Osteosarcoma causes large number of deaths because of its complex pathogenesis and resistance to conventional treatment. MicroRNAs are a class of small noncoding RNAs that function as critical gene regulators through targeting mRNAs, causing translational repression or degradation. I...

Toplum ıslâhı her zaman güncelliğini koruyan bir konu olmuştur. Bundan dolayı da tarihin döneminde yaşanan kötü durumu düzeltmek için ıslâh ve değişim çağrısı yapan, değişik isimlerle ortaya çıkan toplum ıslâhına çözüm sunmaya çalışan, çeşitli akım ideolojiler hep var Fakat bu hareketler –bazı yönlerden muvafık olmuşlarsa da- kapsamlı gerçekleştirememişlerdir. Ancak tarih, en mükemmel faaliyeti...