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Michael D. Green, B.S., J.D., is Bess & Walter Williams Chair in Law, Wake Forest University School of Law, Winston-Salem, North Carolina. D. Michal Freedman, J.D., Ph.D., M.P.H., is Epidemiologist, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland. Leon Gordis, M.D., Dr.P.H., is Professor of Epidemiology, Johns Hopkins School of Public Health, and Prof...
UNLABELLED Deregulated cell proliferation and apoptosis play a major role in hepatocellular carcinoma (HCC). MicroRNAs participate in the modulation of key molecules linked to hepatocarcinogenesis. PURPOSE This study aims to investigate the role of miR-221 in the modulation of Bmf, a proapoptotic BH3-only protein, and to characterize miR-221 contribution to hepatocarcinogenesis through modula...
BACKGROUND & AIM The miR-221/222 cluster is upregulated in malignant plasma cells from multiple myeloma (MM) patients harboring the t(4;14) translocation. We previously reported that silencing of miR-221/222 by an antisense oligonucleotide induces anti-MM activity and upregulates canonical miR-221/222 targets. The in vivo anti-tumor activity occurred when miR-221/222 inhibitors were delivered d...
BACKGROUND Physician-assisted suicide was legalized in Oregon in October 1997. There are data on patients who have received prescriptions for lethal medications and died after taking the medications. There is little information, however, on physicians' experiences with requests for assistance with suicide. METHODS Between February and August 1999, we mailed a questionnaire to physicians who w...
1 The Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia 2 CogState Ltd., Melbourne, Victoria, Australia 3 Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA 4 Academic Unit for Psychiatry of Old Age, St. Vincent’s Health, Department of Psychiatry, The University of Melbourne, Kew, Victoria, Australia 5 National Ageing Research Insti...
may be many years in the past. The accuracy of reporting on sensitive matters relating to sexual behavior can also shift as the culture changes, and that accuracy may vary with age. Because, by definition, self-reports of the initiation of sexual activity cannot be externally validated, the scientific literature has necessarily focused on the consistency and reliability of reporting, through tw...
Career choice in medicine is influenced by several factors. Our aim was to look at reasons for choice of anesthesia as a career in a cohort of doctors applying for the residency training in a university hospital in a developing country. A semi-structured interview form is used in our department and includes a question related to career choice. Each applicant is interviewed by two faculty member...
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