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We agree with Suissa and Azoulay (1) that observational studies, particularly those of drug effects, can be subject to biases and that “timerelated” biases must be carefully controlled in these types of studies. In their recently published article (1), Suissa and Azoulay have attempted to “show that several of the observational studies investigating the association between metformin and cancer ...
Sparidae family is one of the most important demersal group for Turkish fisheries. When considering importance Turkey fisheries, population parameters Pagellus acarne Risso, 1827 have a many proposition future fisheries studies. Studies biology and this species are very limited in Aegean Sea; therefore we aimed to determine (length-weight relationship, age growth parameters, mortality rates rep...
BACKGROUND Biomarkers of multiple pathophysiological pathways have been related to incident atrial fibrillation (AF), but their predictive ability remains controversial. METHODS AND RESULTS In 3120 Framingham cohort participants (mean age 58.4+/-9.7 years, 54% women), we related 10 biomarkers that represented inflammation (C-reactive protein and fibrinogen), neurohormonal activation (B-type n...
We have also been able to make satisfactory glass potential measurements in humid summer weather under conditions which would have proved hopeless for the quadrant electrometer. This may be due to the fact that the electrostatic field associated with the 2.3-volt grid circuit is so small in comparison with that present in the vicinity of the electrometer vane (50 volts) that stray atmospheric c...
Background—Biomarkers of multiple pathophysiological pathways have been related to incident atrial fibrillation (AF), but their predictive ability remains controversial. Methods and Results—In 3120 Framingham cohort participants (mean age 58.4 9.7 years, 54% women), we related 10 biomarkers that represented inflammation (C-reactive protein and fibrinogen), neurohormonal activation (B-type natri...
Chemokines are mediators in inflammatory and autoimmune disorders. Aminoterminal truncation of chemokines results in altered specific activities and receptor recognition patterns. Truncated forms of the CXC chemokine interleukin (IL)-8 are more active than full-length IL-8 (1-77), provided the Glu-Leu-Arg (ELR) motif remains intact. Here, a positive feedback loop is demonstrated between gelatin...
have elevated levels of thyroid hormones (Barron, 1986; Hoar, 1988; Datta et al., 1999; Eales, 1990). Thyroid hormones play a central role in controlling many of the alterations in physiology, morphology and behavior noted during this metamorphic transition in juvenile salmon (Hoar, 1988). Thyroid hormones have also been identified in altering the visual system during smoltification. During mig...
BACKGROUND There is currently conflicting evidence surrounding the effects of obesity on postoperative outcomes. Previous studies have found obesity to be associated with adverse events, but others have found no association. The aim of this study was to determine whether increasing body mass index (BMI) is an independent risk factor for development of major postoperative complications. METHOD...
BACKGROUND The guidelines established by the National Comprehensive Cancer Network do not describe mucinous histology as a clinical factor that should influence the therapeutic algorithm. However, previous studies show conflicting results regarding the prognosis of colorectal mucinous adenocarcinoma. In this study, we described the clinicopathological features of mucinous adenocarcinoma in Japa...
Chemokines are mediators in inflammatory and autoimmune disorders. Aminoterminal truncation of chemokines results in altered specific activities and receptor recognition patterns. Truncated forms of the CXC chemokine interleukin (IL)-8 are more active than full-length IL-8 (1-77), provided the Glu-Leu-Arg (ELR) motif remains intact. Here, a positive feedback loop is demonstrated between gelatin...
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