نتایج جستجو برای: 28b
تعداد نتایج: 543 فیلتر نتایج به سال:
The in vitro screening for trypanocidal activity against Trypanosoma brucei rhodesiense of an in-house library of 62 compounds [i.e. alkane, diphenyl, and azaalkane bisguanidines and bis(2-aminoimidazolines)], which were chosen for their structural similarity to the trypanocidal agents synthalin (1,10-decanediguanidine) and 4,4'-diguanidinodiphenylmethane and the polyamine N(1)-(3-amino-propyl)...
In euryhaline teleosts, permeability changes in gill epithelia are essential during acclimation to changed salinity. This study examined expression patterns of branchial tight junction proteins called claudins, which are important determinants of ion selectivity and general permeability in epithelia. We identified Atlantic salmon genes belonging to the claudin family by screening expressed sequ...
Direct-acting antiviral treatment for hepatitis C virus (HCV) infection is costly and does not protect from re-infection. For human and chimpanzees, recovery from acute HCV infection correlates with host CD4+ and CD8+ T cell responses. DNA plasmids targeting the HCV non-structural antigens NS3, NS4, and NS5, were previously reported to induce robust and sustained T cell responses in mice and pr...
بررسی فراوانی الل مطلوب پلی مورفیسم rs۱۲۹۷۹۸۶۰ ژن اینترلوکین ۲۸b در جمعیت سالم و آلوده به hcv ایرانی
زمینه و هدف: ویروس هپاتیت c (hcv) یکی از مهم ترین عوامل خطر در ایجاد سیروز کبد و هپاتوسلولار کارسینوما است. بعضی از عوامل ژنتیکی میزبان می تواند روی میزان پاسخ به درمان ضد ویروسی اثر بگذارد که از این عوامل می توان به اینترلوکین 28b اشاره کرد. اینترلوکین 28b عضوی از خانواده اینترفرون ها بوده که در ایجاد پاسخ های ضد ویروسی اثر گذار است. مطالعات قبلی نشان داده اند که پلی مورفیسم نقطه rs12979860 ژن...
Adjuvant compounds are usually included in vaccinations in order to bolster total vaccine-specific responses or to tailor an immune response toward a desired endpoint, such as the production of gamma interferon or an increase in antibody titers. While most adjuvants are studied in regard to their impact on vaccine-specific responses during and just after the vaccination period, a detailed analy...
BACKGROUND AND AIMS A total of 105 patients were identified as accidentally infected with hepatitis C virus genotype 1b (HCV1b) through blood transfusion from a single blood donor. This group provides a unique patient population to study host factors involved in the spontaneous clearance of HCV and disease progression. METHODS Clinical markers, HCV RNA and eight single nucleotide polymorphism...
BACKGROUND Polymorphisms in the interleukin-28B are important determinants in the spontaneous and drug-induced control of hepatitis C virus infection. DESIGN AND METHODS We assessed the association of rs8099917 and rs12979860 polymorphisms with spontaneous viral clearance, severity of liver fibrosis, and response to interferon-monotherapy in 245 thalassemia major patients with hepatitis C vir...
The Stellar Planet Survey (STEPS) is an ongoing astrometric search for giant planets and brown dwarfs around a sample of 30 M dwarfs. We have discovered several low-mass companions by measuring the motion of our target stars relative to their reference frames. The highest mass discovery thus far is G78-28B, a companion to the M dwarf G78-28A. The orbital period is 4:18 0:03 yr, the system mass ...
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