The appearance of fibrin provides the end-point in every clotting test, and the duration of the thrombin-fibrinogen reaction is thus a component of any measurement of clottinig time' While many tests are designed to study the early stages of clotting, in interpreting the results it is necessary to consider to what extent the observed differences may be due simply to differences in the " indicat...

Blood clotting is a precise cascade engineered to form a clot with temporal and spatial control. Current control of blood clotting is achieved predominantly by anticoagulants and thus inherently one-sided. Here we use a pair of nanorods (NRs) to provide a two-way switch for the blood clotting cascade by utilizing their ability to selectively release species on their surface under two different ...

We present a silica nanoparticle (SNP) functionalized with polyphosphate (polyP) that accelerates the natural clotting process of the body. SNPs initiate the contact pathway of the blood-clotting system; short-chain polyP accelerates the common pathway by the rapid formation of thrombin, which enhances the overall blood-clotting system, both by accelerating fibrin generation and by facilitating...

BACKGROUND Haemorrhage remains the greatest threat to life on the battlefield, accounting for half of all deaths. Over the past decade the US army has widely studied new technologies for stopping sever haemorrhages and has introduced an effective zeolite based haemostatic agent. In this paper the bio-stimulatory effect of burned radioactive lantern mantles powder as well as two minerals; benton...

We have studied the contribution of platelets to the coagulation of plasma and the effects of activation or inhibition of platelets on the coagulation process in unanticoagulated fresh whole blood (subsequently termed native blood). For this purpose, we have used a free oscillation rheometer (FOR), the ReoRox4, a new instrument that enables noninvasive viscoelastic measurements of clot formatio...

BACKGROUND Circadian variations have been described for a number of haemostatic and physiological factors, all of which might predispose towards clotting in the late morning. The anticoagulation effect of heparin has been shown to respond in a circadian manner, resulting in minimal prolongation of the activated partial thromboplastin time (aPTT) in the morning. METHODS Recombinant hirudin (HB...

By FRANK MALTANER, PH.D., AND JosE 0. DE ALMEIDA, M.D. T HE CLOSE relationship between the role of calcium in the clotting and complement activities of serum has already been shown.’ More recent studies have demonstrated the effect of magnesium in the hemolytic activity of complement’ and in the clotting reaction.3 Since it is well known that magnesium salts do not replace calcium in the clotti...

PURPOSE The aim of the study is the examination of effects of dipeptides containing S-hexyl-L-cysteine and glycine, on the prothrombin activation and the thrombin clotting time determined in the presence of heparin. MATERIAL AND METHODS The activation of prothrombin was determined with the use of the thromboplastin test, the recalcification and partial thromboplastin with kaolin tests. The th...

In medicine, blood groups play an active role. A noticeable relationship is observed linking ABO with the Wilbrand factor and vWF deficiency which results in hemorrhagic disorders, while increased levels are a risk for clotting. Previous investigations found that individuals group O have long hemorrhageand clotting time. The aim of current study to evaluate bleeding time different sex also. Thi...