Oximes, its ether derivatives and the corresponding hydroxylamines rearrange to secondary amines when reacted with PhSiH3 B(C6F5)3 as catalyst. Computations suggest a reduction–rearrangement be slightly favored over Beckmann-type sequence.

A broad range of secondary and tertiary amides has been hydrogenated to the corresponding amines under mild conditions using an in situ catalyst generated by combining [Ru(acac)3], 1,1,1tris(diphenylphosphinomethyl)ethane (Triphos) and Yb(OTf)3. The presence of the metal triflate allows to mitigate reaction conditions compared to previous reports thus improving yields and selectivities in the d...

SYNTHESIS OF 3H-LABELED SYMPATHOMIMETIC AMINES FOR NEURONAL MAPPING' Marcian E. Van Dort, David L. Gildersleeve and Donald M. Wieland Division of Nuclear Medicine, University of Michigan, Ann Arbor, MI 48109-0552 Summary The synthesis of two tritium labeled sympathomimetic amines, (R)-(-)-phenylephrine and (1 R,2S)( ) -whydroxyephedrine, is described. The tritium label was introduced into the a...

6-Methyl-2-phenyl-7H-Oxazolo [3,2-b] [1,2,4] triazine (1) undersent ting transformation on treatment with ammonia and primary amines to afford the corresponding imidazol [1,2-b][1,2,4] triazine (2). Treatment of (1) with hydrazine hydrate gave the corresponding 3-aryl-4H-1,2,4- triazino [4,3-b][1,2,4] triazin-8 (1H)-one (3).

Heterocyclic amines are formed during high temperature cooking of foods such as meat and fish. Although heterocyclic amines are known mutagens and some of them are shown to be carcinogenic to experimental animals, the carcinogenic potential of heterocyclic amines in humans has yet to be established. The most important criteria in determining the relationship between heterocyclic amines and huma...