Abstract: Objectives: Female population frequently seeks medical consultation for the vaginal candidiasis. Voriconazole (VOR) is a BCS class II antifungal drug with low aqueous solubility and hence inclusion complex was formulated using Hydroxypropyl-β-cyclodextrin (HPβCD). The incorporated into mucoadhesive tablet Chitosan Hydroxypropyl Methyl Cellulose (HPMC K100). Materials Methods: A 32 ful...

in order to achieve prolong corneal contact time of norfloxacin(nfx) for treatment of extra ocular diseases, a ph triggered nanoparticulate in situ gelling system was designed to explore dual advantage of nanoparticles and in situ gelling system, for its ocular delivery. nfx loaded nanocarriers were developed by ionotropic gelation technique using chitosan as a matrix forming polymer, cross-lin...

OBJECTIVE To examine the factor structure of the 144-item Chinese version of the Temperament and Character Inventory (TCI) and its association with age and gender in a large non-clinical population. METHOD We recruited 1966 non-clinical participants in China who completed the TCI Chinese version. They were randomly divided into two independent samples. One sample (n=983) was used for explorat...

Two experiments evaluated the self-handicapping hypothesis that alcohol consumption varies directly with individuals' uncertainty of their ability to perform successfully. In a 2 X 2 X 2 factorial design, Experiment 1 manipulated (a) difficulty of an initial intellectual test (insolvable or solvable), (b) feedback regarding test performance (success or none), and (c) instructions regarding the ...

Recent literature has proposed integrating observed noise variables into a factorial design structure as an alternative robust design strategy. Because noise factors are often difficult to control or randomize, observing their values may be useful. This research compares existing alternatives involving unreplicated fractional factorial designs and observable noise factors.

Nateglinide is a novel, highly physiologic, glucose regulator recently approved for the treatment of type-2 diabetes mellitus. Nateglinide has a rapid onset and short duration of insulinotropic action that results in reduction of glucose level. The purpose of this study to develop a floating tablet of Nateglinide to enhance its bioavailability and sustained action. In the present study a 32 ful...

BACKGROUND The evaluation of more than one intervention in the same randomised controlled trial can be achieved using a parallel group design. However this requires increased sample size and can be inefficient, especially if there is also interest in considering combinations of the interventions. An alternative may be a factorial trial, where for two interventions participants are allocated to ...