In a retrospective analysis, paradoxical deterioration of lymph node tuberculosis in human immunodeficiency virus-uninfected patients was common, occurring in 25 (23%) of 109 patients after treatment had been given for a median of 46 days (interquartile range, 21-139 days) and persisting for a median of 67.5 days (interquartile range, 34-111 days). We found no association between the use of ste...

Some of the achievements at festivities and exhibitions are greeted with surprise. It is not always possible to have the privilege of personal inspection, though those in charge of defectives are usually most ready to give of their precious leisure in showingvisitors what is being done.. The following notes giving different accounts of Christmas activities have been kindly sent to us. They may ...

When does a human being begin to exist? We argue that it is possible, through a combination of biological fact and philosophical analysis, to provide a definitive answer to this question. We lay down a set of conditions for being a human being, and we determine when, in the course of normal fetal development, these conditions are first satisfied. Issues dealt with along the way include: modes o...

A maintenance medium for Treponema pallidum was designed to hold its Eh at the optimum for that organism, -10 to -110 mV. After 100% motile (freshly harvested) T. pallidum was inoculated into the medium, the motility of the treponemes decreased to 80% after 2 days, 50% after 3.5 days, and 0% after 9 days during incubation at 34 C. Full virulence was retained for 2 days, but it dropped rapidly t...

Shivering, you drag yourself, as if gun-shot, to the living room, to the old movie channel, to a Bogart festival, your mind fogged over (like the street on the screen) edging toward feverish sleep when Bogey snarls at Ida Lupino: “Of all the 14-carat saps...” Hours later when you wake, he’s smacking Peter Lorre: “When you’re slapped, you’ll take it and like it!” And as if cuffed, you black out,...

within 21 days. The likelihood ratio for a negative result [(1 sensitivity)/specificity] was 0.59 for birth within 7 days, 0.68 for birth within 14 days, and 0.53 for birth within 21 days. The data in Table 1 are similar to those obtained in previous studies using the ELISA-based assay. Joffe et al. (1 ) reported a NPV of 99.6% and a PPV of 9.1% for 243 patients who delivered within 7 days with...

OBJECTIVE We previously demonstrated that upregulation of intermediate-conductance Ca(2+)-activated K(+) channels (K(Ca)3.1) is necessary for mitogen-induced phenotypic modulation in isolated porcine coronary smooth muscle cells (SMCs). The objective of the present study was to determine the role of K(Ca)3.1 in the regulation of coronary SMC phenotypic modulation in vivo using a swine model of ...