نتایج جستجو برای: 341
تعداد نتایج: 4464 فیلتر نتایج به سال:
Although chronic Pseudomonas aeruginosa infection is the major cause of morbidity and mortality in cystic fibrosis (CF) patients, there is no approved vaccine for human use against P. aeruginosa. The goal of this study was to establish whether a multivalent vaccine containing P. aeruginosa type A and B flagellins as well as the outer membrane proteins OprF and OprI would promote enhanced cleara...
The transcription factor NF-kappaB activates a number of genes whose protein products are proinflammatory. In quiescent cells, NF-kappaB exists in a latent form and is activated via a signal-dependent proteolytic mechanism in which the inhibitory protein IkappaB is degraded by the ubiquitin-proteasome pathway. Consequently, inhibition of the proteasome suppresses activation of NF-kappaB. This s...
Treatment with the proteasome inhibitor, PS-341 resulted in concentration- and time-dependent effects on Bcl-2 phosphorylation and cleavage in H460 cells that coincided with the PS-341-induced G2-M phase arrest. The observed Bcl-2 cleavage paralleled the degree of PS-341-induced apoptosis but was detected to a similar extent with comparable concentrations of two other proteasome inhibitors (MG-...
, 1185 (2013); 341 Science Helen S. Margolis Opportunities Knock with a More Stable Optical Clock This copy is for your personal, non-commercial use only. clicking here. colleagues, clients, or customers by , you can order high-quality copies for your If you wish to distribute this article to others here. following the guidelines can be obtained by Permission to republish or repurpose articles...
for all integers a. This result gives us the rudimentary Fermat Compositeness Test: If a 6≡ a (mod n) for some integer a, then n is composite. While this has the advantage of being computationally simple, it has the distinct disadvantage of failing for some composite n and choice of a. Take, for example, n = 341 = 31 · 11 and a = 2. A quick computation tells us that 2 ≡ 2 (mod 341). Fortunately...
The receptor activator of nuclear factor κB ligand/receptor activator of nuclear factor κB (RANKL/RANK) pathway is crucial for the migration of RANK-expressing cancer cells. The ubiquitin-proteasome protein degradation pathway plays a significant role in tumor metastasis. However, the relationship between these two pathways in tumor cell migration is unclear. In the present study, we explored t...
The objectives of this study were to (1) assess the role of the 26S proteasome complex in regulating the expression of the inducible isoform of nitric oxide synthase (iNOS) and vascular cell adhesion molecule-1 (VCAM-1) in a model of chronic granulomatous colitis in vivo and (2) determine the role of the proteasome in regulating the inflammatory response observed in this model of chronic gut in...
Psoriasis is a chronic inflammatory skin disease caused by an IL-23- and IL-17 driven immune response. Monocytes are regarded as key regulatory cells, which can be divided into three well-defined subsets: classical monocytes, intermediate non-classical monocytes (ncMo). The function of ncMo in inflammation remains largely unknown. Yet, our previous studies on slan+ (6-sulfo LacNAc) suggested th...
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